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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lu, Mong-Liang Wang, Tsu-Nai Lin, Tsang-Yaw Shao, Wen-Chuan Chang, Sheng-Huang Chou, Jen-Yu Ho, Yi-Feng Liao, Yin-To Chen, Vincent Chin-Hung |
| Description | Country affiliation: Taiwan Author Affiliation: Lu ML ( Department of Psychiatry, Wan-Fang Hospital and School of Medicine, Taipei Medical University, Taipei, Taiwan.); Wang TN ( Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan.); Lin TY ( Tsaotun Psychiatric Center Department of Health, Nan-Tou, Taiwan.); Shao WC ( Tsaotun Psychiatric Center Department of Health, Nan-Tou, Taiwan.); Chang SH ( Tsaotun Psychiatric Center Department of Health, Nan-Tou, Taiwan.); Chou JY ( Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan.); Ho YF ( Institute of Medicine, Chung Shan Medical University Taichung, Taiwan.); Liao YT ( Institute of Medicine, Chung Shan Medical University Taichung, Taiwan); Chen VC ( Institute of Medicine, Chung Shan Medical University Taichung, Taiwan) |
| Abstract | Second-generation antipsychotics (SGAs) have been associated with an increased liability for weight gain and metabolic side effects. Among SGAs, clozapine and olanzapine had great liability to induce weight gain and metabolic adverse reactions. Leptin, adiponectin, and total ghrelin play important roles in energy homeostasis and are suggested to be biomarkers of metabolic disturbances. The purpose of the present study was to investigate the differential effects of antipsychotics (olanzapine and clozapine) on the levels of adipocytokines (leptin and adiponectin) and total ghrelin. Three hundred and thirty-three patients with schizophrenia under clozapine or olanzapine monotherapy were recruited. Control participants were recruited from a healthy community population based on a health investigation (N=119). Fasting blood samples for glucose, cholesterol, triglycerides, leptin, adiponectin, and total ghrelin were analyzed. There were significant differences in the levels of cholesterol, triglycerides, and glucose between these three groups. Post hoc comparisons showed that the olanzapine group had the highest levels of cholesterol and triglycerides. The levels of leptin, adiponectin, and total ghrelin were also significantly different between the three groups after controlling age and body mass index (BMI). Post hoc comparisons showed that the olanzapine group had the lowest levels of adiponectin and total ghrelin. The present study found that the uses of olanzapine and clozapine were associated with changes in adipocytokines and total ghrelin, even after adjusting potential confounding factors. Olanzapine had greater influences on adiponectin and total ghrelin than clozapine. The changes in adipocytokines and total ghrelin were a direct effect of antipsychotics on hormonal pathways of energy homeostasis, rather than the result of weight gain. |
| File Format | HTM / HTML |
| ISSN | 02785846 |
| Volume Number | 58 |
| e-ISSN | 18784216 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-03 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Psychiatry Adipokines Blood Antipsychotic Agents Therapeutic Use Benzodiazepines Clozapine Ghrelin Schizophrenia Drug Therapy Adult Aging Drug Effects Blood Glucose Metabolism Body Mass Index Cholesterol Fasting Female Humans Male Middle Aged Triglycerides Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Pharmacology |
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