NDLI: The role of monoamine oxidase A in aggression: Current translational developments and future challenges.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Godar, Sean C. Fite, Paula J. McFarlin, Kenneth M. Bortolato, Marco
Description	Country affiliation: United States Author Affiliation: Godar SC ( Department of Pharmacology and Toxicology, University of Kansas, Lawrence, (KS), USA); Fite PJ ( Consortium for Translational Research on Aggression and Drug Abuse (ConTRADA), University of Kansas, Lawrence, (KS), USA); McFarlin KM ( Department of Pharmacology and Toxicology, University of Kansas, Lawrence, (KS), USA); Bortolato M ( Department of Pharmacology and Toxicology, University of Kansas, Lawrence, (KS), USA)
Abstract	Drawing upon the recent resurgence of biological criminology, several studies have highlighted a critical role for genetic factors in the ontogeny of antisocial and violent conduct. In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. The interest on the link between MAOA and aggression was originally sparked by Han Brunner's discovery of a syndrome characterized by marked antisocial behaviors in male carriers of a nonsense mutation of this gene. Subsequent studies showed that MAOA allelic variants associated with low enzyme activity moderate the impact of early-life maltreatment on aggression propensity. In spite of overwhelming evidence pointing to the relationship between MAOA and aggression, the neurobiological substrates of this link remain surprisingly elusive; very little is also known about the interventions that may reduce the severity of pathological aggression in genetically predisposed subjects. Animal models offer a unique experimental tool to investigate these issues; in particular, several lines of transgenic mice harboring total or partial loss-of-function Maoa mutations have been shown to recapitulate numerous psychological and neurofunctional endophenotypes observed in humans. This review summarizes the current knowledge on the link between MAOA and aggression; in particular, we will emphasize how an integrated translational strategy coordinating clinical and preclinical research may prove critical to elucidate important aspects of the pathophysiology of aggression, and identify potential targets for its diagnosis, prevention and treatment.
File Format	HTM / HTML
ISSN	02785846
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume Number	69
e-ISSN	18784216
Language	English
Publisher	Elsevier
Publisher Date	2016-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Pharmacology

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