NDLI: Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways.

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Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways.

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Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Senthil Kumar, K. J. Wang, Sheng-Yang
Description	Country affiliation: Taiwan Author Affiliation: Senthil Kumar KJ ( Department of Forestry, National Chung-Hsing University, Taichung, Taiwan.)
Abstract	The anti-inflammatory mechanism of lucidone isolated from the fruits of Lindera erythrocarpa Makino was investigated. Our data indicate that lucidone significantly inhibits the production of NO and PGE(2) autacoids in LPS-induced RAW 264.7 murine macrophage cells. Moreover, it also notably decreased the secretion of tumor necrosis factor-alpha (TNF-alpha). Consistent with these observations, the mRNA and protein expression levels of iNOS and COX-2 were also inhibited by lucidone in a dose-dependent manner. Lucidone also reduced the translocation of NF-kappaB induced by LPS, which is associated with the prevention of the degradation of I-kappaB, and subsequently decreased p65/p50 protein levels in the nucleus. Lucidone also inhibited NF-kappaB activation by impairing the binding of NF-kappaB to its cis-acting element. In addition, lucidone inhibited JNK and p38MAPKs signals, which are the most significant signals involved in NO, PGE(2) and TNF-alpha production; NF-kappaB/AP-1 activation was also inhibited by lucidone. Taken together, the anti-inflammatory activity of lucidone might be caused by the inhibition of iNOS and COX-2 expressions through downregulation of NF-kappaB and AP-1 binding.
File Format	HTM / HTML
ISSN	00320943
Issue Number	5
Volume Number	75
e-ISSN	14390221
Journal	Planta Medica
Language	English
Publisher	George Thieme
Publisher Date	2009-04-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Botany Anti-inflammatory Agents Pharmacology Cyclooxygenase 2 Inhibitors Cyclopentanes Macrophages Drug Effects Mitogen-activated Protein Kinases Antagonists & Inhibitors Nf-kappa B Nitric Oxide Synthase Type Ii Animals Isolation & Purification Cell Culture Techniques Dinoprostone Biosynthesis Gene Expression Jnk Mitogen-activated Protein Kinases Lindera Chemistry Lipopolysaccharides Metabolism Male Mice Nf-kappa B P50 Subunit Nitric Oxide Plant Extracts Protein Transport Rna, Messenger Signal Transduction Transcription Factor Ap-1 Tumor Necrosis Factor-alpha P38 Mitogen-activated Protein Kinases Journal Article
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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