NDLI: Chemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Meng-Li Xian, Yan-Fang Ip, Siu-Po Tsai, Sam-Hip Yang, Ji-Yong Che, Chun-Tao
Description	Country affiliation: Hong Kong Author Affiliation: Chen ML ( School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.âT., Hong Kong.)
Abstract	The Chinese herbal drug Cortex Phellodendri is derived from two species of PHELLODENDRON, P. CHINENSIS Schneid. and P. AMURENSE Rupr. Traditionally, Cortex Phellodendri Chinensis (CPC) and Cortex Phellodendri Amurensis (CPA) are used interchangeably because they are believed to share the same clinical efficacy. Berberine has been believed to be the active ingredient of the herbs. However, recent studies have shown that the content of berberine is much higher in CPC than in CPA. Interestingly, the majority of researches deal with CPA, the one with lower content of berberine. These observations provoke us to reconsider the active ingredients of Cortex Phellodendri. In this study, two traditional usages (antidiarrheal and antibacterial) of Cortex Phellodendri were compared with the chemical analysis of the two herb species used in its formulation. The results suggest that berberine is one of the active ingredients responsible for the antidiarrheal and antibacterial activities of the herbs, but that other chemical ingredients are also involved in regulating the biological actions of the herbal drug. These chemical ingredients may have the same or the opposite effect as berberine. The effectiveness of the herbs is more likely to correlate to the content of total alkaloids rather than to the content of berberine.
File Format	HTM / HTML
ISSN	00320943
Issue Number	14
Volume Number	76
e-ISSN	14390221
Journal	Planta Medica
Language	English
Publisher	George Thieme
Publisher Date	2010-10-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Botany Anti-bacterial Agents Pharmacology Antidiarrheals Berberine Alkaloids Berberine Drugs, Chinese Herbal Phellodendron Chemistry Animals Isolation & Purification Escherichia Coli Drug Effects Female Gastrointestinal Motility Mice Mice, Inbred Balb C Microbial Sensitivity Tests Pseudomonas Aeruginosa Comparative Study Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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