NDLI: Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid.

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Modulation of antibiotic resistance in bacterial pathogens by oleanolic acid and ursolic acid.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kurek, Anna Nadkowska, Paulina Pliszka, Sylwia Wolska, Krystyna I.
Description	Country affiliation: Poland Author Affiliation: Kurek A ( Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland. annakurek@biol.uw.edu.pl)
Abstract	Antibiotic resistance among bacterial pathogens is a serious problem for human and veterinary medicine, which necessitates the development of novel therapeutics and antimicrobial strategies. Some plant-derived compounds, e.g. pentacyclic triterpenoids such as oleanolic acid (OA) and ursolic acid (UA), have potential as a new class of antibacterial agents as they are active against many bacterial species, both Gram-positive and Gram-negative, and specifically target the cell envelope. The aim of the present study was to investigate the influence of OA and UA on the susceptibility of four bacterial pathogens (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus aureus and Staphylococcus epidermidis) to the ß-lactam antibiotics ampicillin (Ap) and oxacillin (Ox). Antimicrobial assays were conducted with bacteria growing in liquid suspension cultures (planktonic cells) or as biofilms. Using FICI value estimation and the time-kill method it was demonstrated that in some combinations, the tested compounds acted in synergy to lower the susceptibility of S. aureus, S. epidermidis and L. monocytogenes to ampicillin and oxacillin, but no synergy was observed for P. aeruginosa. These results indicate that OA and UA may be useful when administered in combination with ß-lactam antibiotics to combat bacterial infections caused by some Gram-positive pathogens.
File Format	HTM / HTML
ISSN	09447113
Issue Number	6
Volume Number	19
e-ISSN	1618095X
Journal	Phytomedicine
Language	English
Publisher	Elsevier
Publisher Date	2012-04-15
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Complementary Therapies Anti-bacterial Agents Pharmacology Drug Resistance, Microbial Drug Effects Gram-positive Bacteria Oleanolic Acid Triterpenes Administration & Dosage Drug Evaluation Drug Therapy, Combination Gram-negative Bacteria Humans Listeria Monocytogenes Phytotherapy Plant Extracts Pseudomonas Aeruginosa Staphylococcus Aureus Staphylococcus Epidermidis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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