NDLI: Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yuan, Peixiong Tragon, Tyson Xia, Menghang Leclair, Christopher A. Skoumbourdis, Amanda P. Zheng, Wei Thomas, Craig J. Huang, Ruili Austin, Christopher P. Chen, Guang Guitart, Xavier
Description	Country affiliation: United States Author Affiliation: Yuan P ( Biomarker Laboratory, National Institute of Mental Health, Mood and Anxiety Disorders Program, National Institutes of Health, Bethesda, MD 20892, USA.)
Abstract	Pleasure-seeking deficits, including lack of libido, are a core feature of depression. Animal and preliminary clinical studies both suggest that phosphodiesterase 4 (PDE4) is a target for developing novel antidepressants. This study examined the potential involvement of PDE4 in the pathology of depression in both animal models and human postmortem brains. In humans, PDE4B and PDE4D levels were elevated in cingulate cortical tissue from individuals with major depressive disorder (MDD) compared to controls. Using the female urine smelling test (FUST), a recently refined method for monitoring sexual pleasure-seeking activity in mice, we found that icv infusion of selective potent PDE4 inhibitors enhanced sexual pleasure-seeking activity in male mice that underwent the learned helplessness or serotonin depletion paradigms. The infusion also increased sexual pleasure-seeking activity in naïve male mice. The results suggest that PDE4 may be a plausible contributor to the sexual pleasure-seeking deficits seen in depressed patients; inhibiting PDE4 may restore these deficits.
File Format	HTM / HTML
ISSN	00913057
e-ISSN	18735177
DOI	10.1016/j.pbb.2011.02.001
Journal	Pharmacology Biochemistry and Behavior
Issue Number	3
Volume Number	98
Language	English
Publisher	Elsevier
Publisher Date	2011-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Phosphodiesterase 4 Inhibitors Pharmacology Sexual Behavior, Animal Drug Effects Animals Blotting, Western Mice Research Support, N.i.h., Intramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology

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Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

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Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

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Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.