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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khalki, Hanane Khalki, Loubna Aboufatima, Rachida Ouachrif, Abderrahim Mountassir, Maryam Benharref, Ahmed Chait, Abderrahman |
| Description | Country affiliation: Morocco Author Affiliation: Khalki H ( Laboratory of Pharmacology, Neurobiology and Behavior, Department of Biology, Faculty of Sciences Semlalia University Cadi Ayyad, Marrakech, Morocco. hanane.neurosc@yahoo.fr) |
| Abstract | Tobacco exposure is not only a health concern for adults but has also been shown to exert deleterious effects on the health of the fetus, newborn, child, and adolescent. Decreased cognitive function, lower Intellectual Quotient (IQ) and deficits in learning and memory in children have been associated with maternal smoking during pregnancy. In this study, we have studied the effect of a tobacco plant extract on the growth and development in the rat. The extract contained relative proportions of alkaloids, including nicotine, purified by chemical separation. Pregnant rats received oral doses of either control (NaCl) or tobacco extract during the entire gestational period. Offspring length and body weight were measured. Each day, the offspring were observed for the following physical parameters: hair growth, incisor eruption and eye opening. The day of appearance of these developments was recorded. Before weaning, the offspring were examined to test their cliff avoidance response (6 postnatal day (PN)), surface righting reflex (05, 07, 13 postnatal day), swimming development (10, 12 postnatal day), negative geotaxis response (7,9,13 and 17 postnatal day) and jumping down choice cage (15, 17 postnatal day). Administration of tobacco extract to dams during the entire gestation period affects behavior and development in pups. The observed effects were a delay in opening eyes, incisor eruption and hair appearance, behavioral developments and an alteration in the rate of success behavior. However, in the jumping down choice cage test there was no difference compared to control animals. The results suggest that tobacco extract has a significant effect on the development of behavioral patterns, orientation and motor coordination and function. They also suggest significant growth retardation and teratogenic effects. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 3 |
| Volume Number | 101 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Solanaceous Alkaloids Toxicity Tobacco Animals Animals, Newborn Behavior, Animal Drug Effects Female Fetal Development Male Motor Activity Nicotine Administration & Dosage Orientation Plant Extracts Pregnancy Prenatal Exposure Delayed Effects Psychomotor Performance Rats Rats, Sprague-dawley Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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