NDLI: Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Richey, Laura Doremus-Fitzwater, Tamara L. Buck, Hollin M. Deak, Terrence
Description	Country affiliation: United States Author Affiliation: Richey L ( Behavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902-6000, USA.)
Abstract	Exposure to an immunogen results in a constellation of behavioral changes collectively referred to as 'sickness behaviors,' with alterations in cytokine expression previously shown to contribute to this sickness response. Since behaviors observed during ethanol withdrawal are strikingly similar to sickness behaviors, we hypothesized that behavioral manifestations of ethanol withdrawal might be an expression of sickness behaviors induced by ethanol-related changes in peripheral and/or central cytokine expression. Accordingly, behaviors exhibited during a modified social investigation test were first characterized in male rats following an acute injection of lipopolysaccharide (LPS; 100µg/kg). Subsequently, behavioral changes after either a high (4-g/kg; Experiment 2) or low dose (0.5g/kg; Experiment 3) of ethanol were also examined in the same social investigation test, as well as in the forced-swim test (FST; Experiment 4). Results from these experiments demonstrated similar reductions in both exploration and social investigatory behavior during acute illness and ethanol withdrawal, while a seemingly paradoxical decrease in immobility was observed in the FST during acute ethanol withdrawal. In follow-up studies, neither indomethacin (Experiment 5) nor interleukin-1 receptor antagonist (Experiment 6) pre-exposure reversed the ethanol withdrawal-induced behavioral changes observed in this social investigation test. Taken together, these studies demonstrate that the behavioral sequelae of acute illness and ethanol withdrawal are similar in nature, while antagonist studies suggest that these behavioral alterations are not reversed by blockade of IL-1 receptors or inhibition of prostaglandin synthesis. Though a direct mechanistic link between cytokines and the expression of acute ethanol withdrawal-related behaviors has yet to be found, future studies examining the involvement of brain cytokines as potential mediators of ethanol effects are greatly needed.
File Format	HTM / HTML
ISSN	00913057
e-ISSN	18735177
DOI	10.1016/j.pbb.2012.08.004
Journal	Pharmacology Biochemistry and Behavior
Issue Number	2
Volume Number	103
Language	English
Publisher	Elsevier
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Behavior, Animal Ethanol Adverse Effects Substance Withdrawal Syndrome Psychology Acute Disease Animals Rats, Sprague-dawley Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure

Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats.

Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats.

Effects of adolescent onset voluntary drinking followed by ethanol vapor exposure on subsequent ethanol consumption during protracted withdrawal in adult Wistar rats.

Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol.

Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats.

Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.

Effects of acute ethanol administration and chronic stress exposure on social investigation and 50kHz ultrasonic vocalizations in adolescent and adult male Sprague-Dawley rats.

SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats.

Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure.

Similar Documents

Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure

Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats.

Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats.

Effects of adolescent onset voluntary drinking followed by ethanol vapor exposure on subsequent ethanol consumption during protracted withdrawal in adult Wistar rats.

Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol.

Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats.

Dopamine and glutamate release in the dorsolateral caudate putamen following withdrawal from cocaine self-administration in rats.

Effects of acute ethanol administration and chronic stress exposure on social investigation and 50kHz ultrasonic vocalizations in adolescent and adult male Sprague-Dawley rats.

SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats.

Acute illness-induced behavioral alterations are similar to those observed during withdrawal from acute alcohol exposure.