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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brigatte, Patricia Konno, Katsuhiro Gutierrez, Vanessa Pacciari Sampaio, Sandra Coccuzzo Zambelli, Vanessa Olzon Picolo, Gisele Curi, Rui Cury, Yara |
| Description | Country affiliation: Brazil Author Affiliation: Brigatte P ( Laboratório Especial de Dor e Sinalização e Laboratório de Fisiopatologia, Instituto Butantan, Av. Vital Brazil 1500, 05503-900 Sao Paulo, SP, Brazil.) |
| Abstract | Cancer pain is an important clinical problem and may not respond satisfactorily to the current analgesic therapy. We have characterized a novel and potent analgesic peptide, crotalphine, from the venom of the South American rattlesnake Crotalus durissus terrificus. In the present work, the antinociceptive effect of crotalphine was evaluated in a rat model of cancer pain induced by intraplantar injection of Walker 256 carcinoma cells. Intraplantar injection of tumor cells caused the development of hyperalgesia and allodynia, detected on day 5 after tumor cell inoculation. Crotalphine (6 µg/kg), administered p.o., blocked both phenomena. The antinociceptive effect was detected 1 h after treatment and lasted for up to 48 h. Intraplantar injection of nor-binaltorphimine (50 g/paw), a selective antagonist of κ-opioid receptors, antagonized the antinociceptive effect of the peptide, whereas N,N-diallyl-Tyr-Aib-Phe-Leu (ICI 174,864, 10 µg/paw), a selective antagonist of δ-opioid receptors, partially reversed this effect. On the other hand, D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr amide (CTOP, 20 g/paw), an antagonist of µ-opioid receptors, did not modify crotalphine-induced antinociception. These data indicate that crotalphine induces a potent and long lasting opioid-mediated antinociception in cancer pain. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 109 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Analgesics Pharmacology Disease Models, Animal Neoplasms Complications Pain Drug Therapy Peptides Receptors, Opioid, Delta Physiology Receptors, Opioid, Kappa Administration, Oral Administration & Dosage Animals Cell Line, Tumor Etiology Rats Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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