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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wakeford, Alison G. P. Riley, Anthony L. |
| Description | Author Affiliation: Wakeford AG ( Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA. Electronic address: alison.presley@gmail.com.); Riley AL ( Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA. Electronic address: alriley@american.edu.) |
| Abstract | Although Fischer (F344) and Lewis (LEW) rats differ in their sensitivity to the rewarding effects of ∆(9)-tetrahydrocannabinol (THC), no data have been reported on differences in their sensitivity to the drug's aversive effects, a limiting factor in drug use and abuse. Examining the degree of differences (if any) in such effects in these strains may help further characterize possible genetic factors important to abuse vulnerability. Accordingly, the aversive effects of THC (1-5.6 mg/kg; intraperitoneal) were examined in 32F344 and 32 LEW subjects using the conditioned taste avoidance (CTA) procedure. Thermoregulation was assessed following an acute injection of THC (same as CTA groups) after a week washout period following the last trial. Subjects in both strains displayed dose-dependent THC-induced taste avoidance, with no significant strain difference. THC induced dose-dependent decreases in core body temperature in both strains. LEW subjects displayed lower core body temperatures than F344 rats, although this effect was independent of THC and was likely stress related. These results were discussed in terms of the nature of THC-induced taste avoidance and the basis of strain differences in the aversive effects of drugs of abuse. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Volume Number | 116 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Avoidance Learning Drug Effects Conditioning, Classical Dronabinol Pharmacology Taste Animals Rats Rats, Inbred F344 Rats, Inbred Lew Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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