NDLI: Neonatal candidiasis: results of an 8 year study.

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Neonatal candidiasis: results of an 8 year study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Celebi, Solmaz Hacimustafaoglu, Mustafa Koksal, Nilgun Ozkan, Hilal Cetinkaya, Merih Ener, Beyza
Description	Country affiliation: Turkey Author Affiliation: Celebi S ( Department of Pediatrics, Division of Pediatric Infectious Diseases, Uludag University Medical Faculty, Gorukle, Bursa, Turkey. solmaz@uludag.edu.tr)
Abstract	BACKGROUND: The aim of the present study was to evaluate the risk factors, demographic features, treatment and clinical outcome associated with candidemia in a neonatal intensive care unit (NICU) within an 8 year period. METHODS: The data of infants who were diagnosed as having candidemia, were evaluated. RESULTS: Between January 2000 and December 2007, a total of 28 candidemia episodes were identified in 28 infants. A 1.1% candidemia incidence was documented in the neonatal intensive care unit (NICU). The species most frequently causing candidemia were Candida parapsilosis (57.1%), followed by C. albicans (42.9%). The main predisposing factors for candidemia with C. parapsilosis included presence of maternal pre-eclampsia, prematurity, prolonged mechanical ventilation, prolonged total parenteral nutrition and presence of jaundice. Retinopathy of prematurity and bronchopulmonary dysplasia were the most frequently seen underlying illnesses in infants with C. parapsilosis. In the present study, 13 infants (46.4%) had evidence of organ dissemination. The mortality rate was 42.8% in infants with candidemia. Mean leukocyte counts and mean C-reactive protein were significantly higher in neonates who died compared with those who survived. CONCLUSION: Candida parapsilosis (57.1%) was the leading causative organism, followed by C. albicans (42.9%) in infants. The rate of organ dissemination in the present cases was high. The mortality rate was 42.8% in infants with candidemia.
File Format	HTM / HTML
ISSN	13288067
Issue Number	3
Volume Number	54
e-ISSN	1442200X
Journal	Pediatrics International
Language	English
Publisher	Wiley
Publisher Date	2012-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pediatrics Candidemia Candida Isolation & Purification Diagnosis Drug Therapy Epidemiology Etiology Microbiology Female Humans Infant, Newborn Male Prospective Studies Risk Factors Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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