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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | de Luis, Daniel A. Sagrado, Manuel González Izaola, Olatz Terroba, Maria Concepcion Cuellar, Luis Conde, Rosa Martin, Tomas |
| Description | Country affiliation: Spain Author Affiliation: de Luis DA ( Institute of Endocrinology and Nutrition, Medical School, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es) |
| Abstract | OBJECTIVE: Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate the fatty acid-binding protein-2 Ala54Thr polymorphism outcomes 1 y after biliopancreatic diversion in morbidly obese patients. METHODS: A sample of 41 morbidly obese patients (body mass index >40 kg/m(2)) were operated upon from December 2004 to December 2006. Weight, fat mass, blood pressure, basal glucose, triacylglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at the basal visit and at each visit. The frequency of patients with diabetes mellitus, hypertension, and hyperlipidemia was recorded at each visit. RESULTS: Twenty-three patients (56.1%) had genotype Ala54/Ala54 (wild group) and 18 patients had genotype Ala54/Thr54 (15 patients, 36.5%) or Thr54/Thr54 (3 patients, 7.4%; mutant group). In the wild group, body mass index, weight, fat mass, systolic blood pressure, glucose, total cholesterol, low-density lipoprotein cholesterol, and triacylglycerol concentrations decreased. Diastolic blood pressure remained unchanged. In the mutant group, the same parameters improved, without statistical differences from the wild group. Initial excess weight percent loss at 1 y of follow-up was similar in both genotype groups (61.8% versus 61.9%, NS). CONCLUSION: Polymorphism Ala54Thr of fatty acid-binding protein did not have an effect on weight loss or clinical outcomes after bariatric surgery. |
| File Format | HTM / HTML |
| ISSN | 08999007 |
| Issue Number | 4 |
| Volume Number | 24 |
| e-ISSN | 18731244 |
| Journal | Nutrition |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Sciences Biliopancreatic Diversion Methods Fatty Acid-binding Proteins Genetics Obesity, Morbid Polymorphism, Genetic Weight Loss Adipose Tissue Metabolism Adult Blood Glucose Blood Pressure Physiology Body Mass Index Cholesterol Blood Female Humans Male Surgery Prospective Studies Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism |
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