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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shibata, Mikihiro Yamashita, Hayato Uchihashi, Takayuki Kandori, Hideki Ando, Toshio |
| Description | Country affiliation: Japan Author Affiliation: Shibata M ( Department of Physics, Kanazawa University, Kanazawa 920-1192, Japan.) |
| Abstract | Dynamic changes in protein conformation in response to external stimuli are important in biological processes, but it has proved difficult to directly visualize such structural changes under physiological conditions. Here, we show that high-speed atomic force microscopy can be used to visualize dynamic changes in stimulated proteins. High-resolution movies of a light-driven proton pump, bacteriorhodopsin, reveal that, upon illumination, a cytoplasmic portion of each bacteriorhodopsin monomer is brought into contact with adjacent trimers. The bacteriorhodopsin-bacteriorhodopsin interaction in the transiently formed assembly engenders both positive and negative cooperative effects in the decay kinetics as the initial bacteriorhodopsin recovers and, as a consequence, the turnover rate of the photocycle is maintained constant, on average, irrespective of the light intensity. These results confirm that high-resolution visualization is a powerful approach for studying elaborate biomolecular processes under realistic conditions. |
| File Format | HTM / HTML |
| ISSN | 17483387 |
| Issue Number | 3 |
| Volume Number | 5 |
| e-ISSN | 17483395 |
| Journal | Nature Nanotechnology |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2010-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nanotechnology Bacteriorhodopsins Chemistry Metabolism Microscopy, Atomic Force Methods Ultrastructure Protein Conformation Protein Multimerization Purple Membrane Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Biomedical Engineering Electrical and Electronic Engineering |
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