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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Carrillo-López, Natalia Román-García, Pablo Rodríguez-Rebollar, Ana Fernández-Martín, José Luis Naves-Díaz, Manuel Cannata-Andía, Jorge B. |
| Description | Country affiliation: Spain Author Affiliation: Carrillo-López N ( Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Universitario Central de Asturias, REDinREN del ISCIII, Universidad de Oviedo, Oviedo, Asturias, Spain.) |
| Abstract | The mechanisms by which estrogens modulate PTH are controversial, including whether or not estrogen receptors (ERs) are present in the parathyroid glands. To explore these mechanisms, we combined a rat model of CKD with ovariectomy and exogenous administration of estrogens. We found that estrogen treatment significantly decreased PTH mRNA and serum levels. We did not observe ERalpha or ERbeta mRNA or protein in the parathyroids, suggesting an indirect action of estrogens on PTH regulation. Estrogen treatment significantly decreased serum 1,25(OH)(2) vitamin D(3) and phosphorus levels. In addition, estrogens significantly increased fibroblast growth factor 23 (FGF23) mRNA and serum levels. In vitro, estrogens led to transcriptional and translational upregulation of FGF23 in osteoblast-like cells in a time- and concentration-dependent manner. These results suggest that estrogens regulate PTH indirectly, possibly through FGF23. |
| File Format | HTM / HTML |
| ISSN | 10466673 |
| e-ISSN | 15333450 |
| DOI | 10.1681/ASN.2008121258 |
| Journal | Journal of the American Society of Nephrology |
| Issue Number | 9 |
| Volume Number | 20 |
| Language | English |
| Publisher | American Society of Nephrology |
| Publisher Date | 2009-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Nephrology Estradiol Metabolism Fibroblast Growth Factors Hyperparathyroidism, Secondary Parathyroid Glands Physiology Parathyroid Hormone Renal Insufficiency, Chronic Animals Bone Density Drug Effects Cell Line, Tumor Pharmacology Estrogen Receptor Alpha Genetics Estrogen Receptor Beta Kidney Osteosarcoma Ovariectomy Rna, Messenger Rats, Sprague-dawley Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
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