| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Xia, Yumin Herlitz, Leal C. Gindea, Simona Wen, Jing Pawar, Rahul D. Misharin, Alexander Perlman, Harris Wu, Lan Wu, Ping Michaelson, Jennifer S. Burkly, Linda C. Putterman, Chaim |
| Description |
Author Affiliation: Xia Y ( Department of Microbiology and Immunology and Division of Rheumatology, Albert Einstein College of Medicine, Bronx, New York); Herlitz LC ( Department of Pathology, Columbia-Presbyterian Medical Center, New York, New York); Gindea S ( Division of Rheumatology, Albert Einstein College of Medicine, Bronx, New York); Wen J ( Department of Microbiology and Immunology and.); Pawar RD ( Department of Microbiology and Immunology and Division of Rheumatology, Albert Einstein College of Medicine, Bronx, New York); Misharin A ( Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois); Perlman H ( Division of Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois); Wu L ( Department of Immunology, Biogen Idec, Cambridge, Massachusetts); Wu P ( Department of Immunology, Biogen Idec, Cambridge, Massachusetts); Michaelson JS ( Tumor Immunology, Jounce Therapeutics, Cambridge, Massachusetts.); Burkly LC ( Department of Immunology, Biogen Idec, Cambridge, Massachusetts); Putterman C ( Department of Microbiology and Immunology and Division of Rheumatology, Albert Einstein College of Medicine, Bronx, New York) |
| Abstract |
TNF ligand superfamily member 12, also known as TNF-related weak inducer of apoptosis (TWEAK), acts through its receptor, fibroblast growth factor-inducible 14 (Fn14), to mediate several key pathologic processes involved in tissue injury relating to lupus nephritis. To explore the potential for renal protection in lupus nephritis by targeting this pathway, we introduced the Fn14 null allele into the MRL-lpr/lpr lupus mouse strain. At 26-38 weeks of age, female Fn14-knockout MRL-lpr/lpr mice had significantly lower levels of proteinuria compared with female wild-type MRL-lpr/lpr mice. Furthermore, Fn14-knockout mice had significantly improved renal histopathology accompanied by attenuated glomerular and tubulointerstitial inflammation. There was a significant reduction in glomerular Ig deposition in Fn14-knockout mice, despite no detectable differences in either serum levels of antibodies or splenic immune cell subsets. Notably, we found that the Fn14-knockout mice displayed substantial preservation of podocytes in glomeruli and that TWEAK signaling directly damaged barrier function and increased filtration through podocyte and glomerular endothelial cell monolayers. Our results show that deficiency of the Fn14 receptor significantly improves renal disease in a spontaneous lupus nephritis model through prevention of the direct injurious effects of TWEAK on the filtration barrier and/or modulation of cytokine production by resident kidney cells. Thus, blocking the TWEAK/Fn14 axis may be a novel therapeutic intervention in immune-mediated proliferative GN. |
| File Format |
HTM / HTML |
| ISSN |
10466673 |
| e-ISSN |
15333450 |
| DOI |
10.1681/ASN.2014030233 |
| Journal |
Journal of the American Society of Nephrology |
| Issue Number |
5 |
| Volume Number |
26 |
| Language |
English |
| Publisher |
American Society of Nephrology |
| Publisher Date |
2015-05-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Nephrology Fibroblast Growth Factors Deficiency Glomerular Filtration Barrier Metabolism Lupus Nephritis Etiology Tumor Necrosis Factors Animals Immunoglobulin G Mice, Knockout Proteinuria Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Nephrology |
