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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Grossman, F. Manji, H. K. Potter, W. Z. |
| Description | Country affiliation: United States Author Affiliation: Grossman F ( Section on Clinical Pharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892, USA.) |
| Abstract | During the past decade, results from radioligand studies comparing platelet (2)-adrenoreceptors in depressed patients and healthy volunteers have been inconsistent, especially when related to the known functional characteristics of these receptors. Despite the availability of radioligands for (2)-adrenoreceptors, inherent methodological problems exist which make data from these studies difficult to interpret. The authors review the overall data from radioligand studies using [(3)H] clonidine and [(3)H] yohimbine of platelet (2)-adrenoreceptors in depressed patients and healthy volunteers. Theoretical and methodological issues are critically examined in the light of recent findings. Finally, alternative strategies for studying ( 2)-adrenoreceptors in clinical populations are considered. |
| File Format | HTM / HTML |
| ISSN | 02698811 |
| Issue Number | 1 Suppl |
| Journal | Journal of Psychopharmacology |
| Volume Number | 7 |
| e-ISSN | 14617285 |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 1993-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) Psychiatry and Mental Health |
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