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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alshetaiwi, Hamad S. Balivada, Sivasai Shrestha, Tej B. Pyle, Marla Basel, Matthew T. Bossmann, Stefan H. Troyer, Deryl L. |
| Description | Author Affiliation: Alshetaiwi HS ( Department of Anatomy and Physiology, 228 Coles Hall, Kansas State University, Manhattan, KS 66506, USA. Electronic address: hamad@ksu.edu.) |
| Abstract | Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes. They are part of the innate immune system and provide a first line of defense by migrating toward areas of inflammation in response to chemical signals released from the site. Some solid tumors, such as breast cancer, also cause recruitment and activation of PMNs and release of myeloperoxidase. In this study, we demonstrate that administration of luminol to mice that have been transplanted with 4T1 mammary tumor cells permits the detection of myeloperoxidase activity, and consequently, the location of the tumor. Luminol allowed detection of activated PMNs only two days after cancer cell transplantation, even though tumors were not yet palpable. In conclusion, luminol-bioluminescence imaging (BLI) can provide a pathway towards detection of solid tumors at an early stage in preclinical tumor models. |
| File Format | HTM / HTML |
| ISSN | 10111344 |
| Volume Number | 127 |
| e-ISSN | 18732682 |
| Journal | Journal of Photochemistry and Photobiology B: Biology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-10-05 |
| Publisher Place | Switzerland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biology Luminescent Agents Metabolism Luminescent Measurements Luminol Mammary Neoplasms, Experimental Pathology Molecular Imaging Animals Benzothiazoles Cell Line, Tumor Female Kinetics Enzymology Mice Mice, Inbred Balb C Peroxidase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Biophysics Radiological and Ultrasound Technology Radiation |
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