NDLI: Host-response therapeutics for periodontal diseases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Giannobile, William V.
Description	Country affiliation: United States Author Affiliation: Giannobile WV ( Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, 24 Frank lloyd Wright Drive, Ann Arbor, MI 48106, USA. wgiannob@umich.edu)
Abstract	Periodontal diseases are initiated by Gram-negative tooth-associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast-related mediators target the destruction of alveolar bone and supporting connective tissues. Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins, and other osteoclast-derived enzymes. This article focuses on the downstream factors of the osteoclast responsible for the degradation of bone and soft tissues around teeth and oral implants. Furthermore, therapeutic approaches that target MMP-2, -8, and -9 inhibition, such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial formulations of tetracycline analogues, are discussed. The use of rapid, chair-side tests of MMP activity, in particular for MMP-8 and bone collagen fragments, show strong potential as non-invasive measures of tissue health or disease. In addition, studies using other agents for the preservation of bone mass, such as bisphosphonates that inhibit osteoclast recruitment, are highlighted. The application of these bone-preservation strategies to periodontal management and treatment are discussed in the context of high-risk patients susceptible to disease reactivation or disease complications.
File Format	HTM / HTML
ISSN	00223492
e-ISSN	19433670
DOI	10.1902/jop.2008.080174
Journal	Journal of Periodontology
Issue Number	8 Suppl
Volume Number	79
Language	English
Publisher	American Academy of Periodontology
Publisher Date	2008-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dentistry Enzyme Inhibitors Therapeutic Use Host-pathogen Interactions Drug Effects Periodontal Diseases Drug Therapy Bone Density Conservation Agents Cathepsins Antagonists & Inhibitors Diphosphonates Gram-negative Bacterial Infections Matrix Metalloproteinase Inhibitors Microbiology Tetracyclines Tissue Inhibitor Of Metalloproteinases Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Periodontics

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Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells.

Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells.

Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases.

Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry.

Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

Regulation of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and extracellular metalloproteinase inducer by interleukin-17 in human periodontal ligament fibroblasts.

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Tumor necrosis factor- induces matrix metalloproteinases-3, -10, and -13 in human periodontal ligament cells.

Host-response therapeutics for periodontal diseases.

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Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells.

Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells.

Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases.

Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry.

Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

Regulation of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and extracellular metalloproteinase inducer by interleukin-17 in human periodontal ligament fibroblasts.

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