NDLI: The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Perunovic, Neda Dj Rakic, Mia M. Nikolic, Ljubinka I. Jankovic, Sasa M. Aleksic, Zoran M. Plecas, Darko V. Madianos, Phoebus N. Cakic, Sasa S.
Description	Author Affiliation: Perunovic NDj ( Department of Periodontology and Oral Medicine, Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia.); Rakic MM ( Institute for Biological Research 'Sinisa Stankovic,' University of Belgrade.); Nikolic LI ( Centre for Osteoarticular and Dental Tissue Engineering, INSERM U791, Faculty of Dental Surgery, University of Nantes, Nantes, France.); Jankovic SM ( Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia.); Aleksic ZM ( Department of Periodontology and Oral Medicine, Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia.); Plecas DV ( Department of Periodontology and Oral Medicine, Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia.); Madianos PN ( Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia.); Cakic SS ( Department of Periodontology, School of Dentistry, University of Athens, Hellas, Greece.)
Abstract	BACKGROUND: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E2 (PGE2), interleukin (IL)-1ß, IL-6, and tumor necrosis factor (TNF)- , in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. METHODS: PGE2, IL-1ß, IL-6, and TNF- levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). RESULTS: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE2 compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1ß, IL-6, and PGE2 and serum levels of TNF- and PGE2 were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE2 were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF- in women with PTB. CONCLUSIONS: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE2 compared with those with FTB. Based on significant correlations among serum PGE2 and PD, CAL, and GCF TNF- in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.
File Format	HTM / HTML
ISSN	00223492
Issue Number	3
Journal	Journal of Periodontology
Volume Number	87
e-ISSN	19433670
Language	English
Publisher	American Academy of Periodontology
Publisher Date	2016-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry
Content Type	Text
Resource Type	Article
Subject	Periodontics

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