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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Özel, S. K. Emir, H. Dervisoglu, S. Akpolat, N. Senel, B. Kazez, A. Söylet, Y. Çetin, G. Danismend, N. Büyükünal, S. N. C. |
| Description | Country affiliation: Turkey Author Affiliation: Özel SK ( Firat University Faculty of Medicine, Department of Pediatric Surgery, Elazig, Turkey. skozel@firat.edu.tr) |
| Abstract | AIM: To investigate histopathological changes in ureteropelvic junction obstruction (UPJO) from an etiological perspective. PATIENTS AND METHODS: Medical records of patients with UPJO were reviewed and pathological specimens collected. Nephrectomy materials from forensic autopsies were taken as controls. Specimens were assessed with light microscopy. Fibronectin, type 4 collagen, laminin, Bax and Bcl-2 expression for apoptosis, together with interstitial cells of Cajal determination with c-kit were determined immunohistochemically. Staining scores were evaluated semiquantitatively. Results were evaluated using Mann-Whitney U-test. RESULTS: Control group comprised 14 children (median age, 3.5 years; 6 months-17 years). Study group comprised 22 children with UPJO (median age, 9 months; 1 month-10 years). Light microscopy revealed non-specific inflammation, epithelial proliferation and atrophy with fibrosis in the smooth muscle of the UPJ in all patients. Fibronectin, type 4 collagen and laminin were found to be significantly increased in UPJO at the intrafascicular space of smooth muscle and the matrix of stroma. Bcl-2 expression was increased in UPJO. c-Kit was unable to stain interstitial cells of Cajal, but staining for mast cells was significant. CONCLUSIONS: High expression of fibronectin, laminin and type 4 collagen may indicate a relation to the pathogenesis of UPJO. Defective kidney morphogenesis, during branching and tubulogenesis of ureteric bud, may be responsible for this congenital pathology. |
| File Format | HTM / HTML |
| ISSN | 14775131 |
| Issue Number | 2 |
| Volume Number | 6 |
| e-ISSN | 18734898 |
| Journal | Journal of Pediatric Urology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Urology Discipline Pediatrics Apoptosis Extracellular Matrix Proteins Metabolism Proto-oncogene Proteins C-kit Ureteral Obstruction Adolescent Child Child, Preschool Collagen Type Iv Female Fibronectins Humans Hydronephrosis Etiology Immunohistochemistry Infant Interstitial Cells Of Cajal Pathology Kidney Pelvis Laminin Male Muscle, Smooth Proto-oncogene Proteins C-bcl-2 Complications Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Urology Pediatrics, Perinatology and Child Health |
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