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The relationship of COX-2 expression with estrogen receptor, progesterone receptor and prognostic parameters in endometrial carcinomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Keser, Sevinç Hallaç Gül, Aylin Ege Barisik, Nagehan Ozdemir Cakir, Caglar Sensu, Sibel Kandemir, Nilüfer Onak Karadayi, Nimet
Description	Country affiliation: Turkey Author Affiliation: Keser SH ( Dr. Lütfi Kirdar Kartal Educational and Research Hospital, Pathology Department, Istanbul, Turkey. sskeser@hotmail.com)
Abstract	AIM: Endometrial cancer (EC), which is the most common gynecologic cancer, develops as a result of disruption of the delicate balance between cell proliferation and cell loss, or apoptosis through activation of oncogenesis, or loss of tumor suppressor genes. Among the biochemical factors proposed to give a more detailed characterization of EC biology, estrogen receptors (ER) and progesterone receptors (PR) play a major role. Most of the studies in the literature have shown increased expression of cyclooxygenase-2 (COX-2) in EC. Recent experiments suggest that COX-2 antagonizes cell apoptosis, increases the invasiveness of malignant cells and promotes angiogenesis. The aim of this study was to investigate the expression of COX-2 in EC, to study its correlation to established menstrual status, grade, myometrial invasion, lymph node status, stage and ER and PR status. MATERIAL & METHODS: The study was performed on 72 ECs. Immunohistochemically was analyzed for ER, PR, and COX-2. RESULTS: COX-2 positivity was found in 91.7% of the cases. In 61 cases (84.7%) there was ER positive staining, and in 59 cases (81.9%) PR positive staining was observed. We have not found a statistically significant relation between COX-2 and prognostic factors, ER and PR. CONCLUSIONS: A high expression rate still suggests a probable relation with endometrial carcinogenesis. If such a relation exists, new therapeutic options might be available in the future.
File Format	HTM / HTML
ISSN	13418076
Issue Number	3
Volume Number	36
e-ISSN	14470756
Journal	Journal of Obstetrics and Gynaecology Research
Language	English
Publisher	Wiley
Publisher Date	2010-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Obstetrics Discipline Gynecology Carcinoma Metabolism Cyclooxygenase 2 Endometrial Neoplasms Receptors, Estrogen Receptors, Progesterone Pathology Female Humans Immunohistochemistry Neoplasm Staging Prognosis Journal Article
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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