NDLI: Four strategies for water transfer of oil-soluble near-infrared-emitting PbS quantum dots.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xue, Bing Cao, Jie Deng, Dawei Xia, Junfei Jin, Jing Qian, Zhiyu Gu, Yueqing
Description	Country affiliation: China Author Affiliation: Xue B ( Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.)
Abstract	The successful transfer of oil-soluble quantum dots (QDs) into water is critical for many of their bioapplications. In this paper, the impacts of four various strategies (i.e., via micelles, nanohydrogels, amphiphilic polymers and water-soluble thiol small molecules) on the phase transfer of oil-soluble oleic acid-capped NIR-emitting PbS QDs into water were evaluated systematically. It was found that the process of water transfer and the optical property of the resulting water-soluble QDs highly hinge on the type of the phase transfer agents used due to their different interactions with QD surface. Among all these phase transfer agents, SOC micelles and glutathione (thiol) molecules are more favorable for retaining the optical property of the initial oil-soluble PbS QDs. As a result, the obtained water-soluble QDs show strong NIR fluorescence (PL QY > 30% in water). However, in the case of nanohydrogel and amphiphilic polymers, the corresponding water-soluble ones display relatively weak fluorescence emission. These results suggest fully that 'correct' phase transfer agents should be selected in order to obtain high-quality water-soluble PbS QDs. The possible reasons for this obvious difference were further analyzed and revealed. Besides, the preliminary results obtained also indicate that the NIR-emitting PbS QDs will be a potential probe in the in vivo biomedical imaging of small animals.
File Format	HTM / HTML
ISSN	09574530
Issue Number	3
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	23
e-ISSN	15734838
Language	English
Publisher	Springer
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering Infrared Rays Lead Chemistry Quantum Dots Sulfides Water Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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