NDLI: Bioactive macroporous titanium implants highly interconnected.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Caparrós, Cristina Ortiz-Hernandez, Mónica Molmeneu, Meritxell Punset, Miguel Calero, José Antonio Aparicio, Conrado Fernández-Fairén, Mariano Perez, Román Gil, Francisco Javier
Description	Country affiliation: Spain Author Affiliation: Caparrós C ( Biomaterials, Biomecànica i Enginyeria de Teixits Department, de Ciència dels Materials i Enginyeria Metal·lúrgica, ETSEIB, Technical University of Catalonia, Barcelona, Spain.); Ortiz-Hernandez M ( Nanoengineering Research Center (CRnE), Technical University of Catalonia, Catalonia, Spain.); Molmeneu M ( Biomaterials, Biomecànica i Enginyeria de Teixits Department, de Ciència dels Materials i Enginyeria Metal·lúrgica, ETSEIB, Technical University of Catalonia, Barcelona, Spain.); Punset M ( Nanoengineering Research Center (CRnE), Technical University of Catalonia, Catalonia, Spain.); Calero JA ( Biomaterials, Biomecànica i Enginyeria de Teixits Department, de Ciència dels Materials i Enginyeria Metal·lúrgica, ETSEIB, Technical University of Catalonia, Barcelona, Spain.); Aparicio C ( Nanoengineering Research Center (CRnE), Technical University of Catalonia, Catalonia, Spain.); Fernández-Fairén M ( Biomaterials, Biomecànica i Enginyeria de Teixits Department, de Ciència dels Materials i Enginyeria Metal·lúrgica, ETSEIB, Technical University of Catalonia, Barcelona, Spain.); Perez R ( Nanoengineering Research Center (CRnE), Technical University of Catalonia, Catalonia, Spain.); Gil FJ ( AMES S.A. Carretera Nacional 340, Pol.Ind. Les Fallulles. S. Vicenç dels Horts, Barcelona, Spain.)
Abstract	Intervertebral implants should be designed with low load requirements, high friction coefficient and low elastic modulus in order to avoid the stress shielding effect on bone. Furthermore, the presence of a highly interconnected porous structure allows stimulating bone in-growth and enhancing implant-bone fixation. The aim of this study was to obtain bioactive porous titanium implants with highly interconnected pores with a total porosity of approximately 57 %. Porous Titanium implants were produced by powder sintering route using the space holder technique with a binder phase and were then evaluated in an in vivo study. The size of the interconnection diameter between the macropores was about 210 µm in order to guarantee bone in-growth through osteblastic cell penetration. Surface roughness and mechanical properties were analyzed. Stiffness was reduced as a result of the powder sintering technique which allowed the formation of a porous network. Compression and fatigue tests exhibited suitable properties in order to guarantee a proper compromise between mechanical properties and pore interconnectivity. Bioactivity treatment effect in novel sintered porous titanium materials was studied by thermo-chemical treatments and were compared with the same material that had undergone different bioactive treatments. Bioactive thermo-chemical treatment was confirmed by the presence of sodium titanates on the surface of the implants as well as inside the porous network. Raman spectroscopy results suggested that the identified titanate structures would enhance in vivo apatite formation by promoting ion exchange for the apatite formation process. In vivo results demonstrated that the bioactive titanium achieved over 75 % tissue colonization compared to the 40 % value for the untreated titanium.
File Format	HTM / HTML
ISSN	09574530
Issue Number	10
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	27
e-ISSN	15734838
Language	English
Publisher	Springer
Publisher Date	2016-10-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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