NDLI: Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.

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Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Yangu Flandin, Pierre Long, Jason E. Cuesta, Melissa Dela Westphal, Heiner Rubenstein, John L. R.
Description	Country affiliation: United States Author Affiliation: Zhao Y ( Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.)
Abstract	Here we analyze the role of the Lhx6 lim-homeobox transcription factor in regulating the development of subsets of neocortical, hippocampal, and striatal interneurons. An Lhx6 loss-of-function allele, which expresses placental alkaline phosphatase (PLAP), allowed analysis of the development and fate of Lhx6-expressing interneurons in mice lacking this homeobox transcription factor. There are Lhx6+;Dlx+ and Lhx6-;Dlx+ subtypes of tangentially migrating interneurons. Most interneurons in Lhx6(PLAP/PLAP) mutants migrate to the cortex, although less efficiently, and exhibit defects in populating the marginal zone and superficial parts of the neocortical plate. By contrast, migration to superficial parts of the hippocampus is not seriously affected. Furthermore, whereas parvalbumin+ and somatostatin+ interneurons do not differentiate, NPY+ interneurons are present; we suggest that these NPY+ interneurons are derived from the Lhx6-;Dlx+ subtype. Striatal interneurons show deficits distinct from pallial interneurons, including a reduction in the NPY+ subtype. We provide evidence that Lhx6 mediates these effects through promoting expression of receptors that regulate interneuron migration (ErbB4, CXCR4, and CXCR7), and through promoting the expression of transcription factors either known (Arx) or implicated (bMaf, Cux2, and NPAS1) in controlling interneuron development.
File Format	HTM / HTML
ISSN	00219967
e-ISSN	10969861
DOI	10.1002/cne.21772
Journal	Journal of Comparative Neurology
Issue Number	1
Volume Number	510
Language	English
Publisher	Wiley
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Cell Differentiation Physiology Homeodomain Proteins Genetics Metabolism Interneurons Cytology Mice Mutation Nerve Tissue Proteins Telencephalon Animals Animals, Newborn Cell Movement Cerebral Cortex Corpus Striatum Embryo, Mammalian Hippocampus Lim-homeodomain Proteins Embryology Growth & Development Mice, Inbred Strains Neocortex Transcription Factors Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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