NDLI: Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.

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Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, Yun Sook Son, Jae Youn Kim, Tae Heon Paik, Sang Kyoo Dai, Yi Noguchi, Koichi Ahn, Dong Kuk Bae, Yong Chul
Description	Author Affiliation: Kim YS ( Department of Oral Anatomy and Neurobiology, Kyungpook National University, Daegu, Korea.)
Abstract	Transient receptor potential ankyrin 1 (TRPA1), responding to noxious cold and pungent compounds, is implicated in the mediation of nociception, but little is known about the processing of the TRPA1-mediated nociceptive information within the trigeminal sensory nuclei (TSN) and the spinal dorsal horn (DH). To address this issue, we characterized the TRPA1-positive (+) neurons in the trigeminal ganglion (TG) and investigated the distribution of TRPA1(+) afferent fibers and their synaptic connectivity within the rat TSN and DH by using light and electron microscopic immunohistochemistry. In the TG, TRPA1 was expressed in unmyelinated and small myelinated axons and also occasionally in large myelinated axons. Many TRPA1(+) neurons costained for the marker for peptidergic neurons substance P (26.8%) or the marker for nonpeptidergic neurons IB4 (44.5%). In the CNS, small numbers of axons and terminals were immunopositive for TRPA1 throughout the rostral TSN, in contrast to the dense network of positive fibers and terminals in the superficial laminae of the trigeminal caudal nucleus (Vc) and DH. The TRPA1(+) terminals contained clear round vesicles, were presynaptic to one or two dendrites, and rarely participated in axoaxonic contacts, suggesting involvement in relatively simple synaptic circuitry with a small degree of synaptic divergence and little presynaptic modulation. Immunoreactivity for TRPA1 was also occasionally observed in postsynaptic dendrites. These results suggest that TRPA1-dependent orofacial and spinal nociceptive input is processed mainly in the superficial laminae of the Vc and DH in a specific manner and may be processed differently between the rostral TSN and Vc.
File Format	HTM / HTML
ISSN	00219967
Issue Number	5
Volume Number	518
e-ISSN	10969861
Journal	Journal of Comparative Neurology
Language	English
Publisher	Wiley
Publisher Date	2010-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neurology Afferent Pathways Metabolism Calcium Channels Nociceptors Posterior Horn Cells Sensory Receptor Cells Trigeminal Nuclei Cytology Animals Ankyrins Axons Ultrastructure Biological Markers Brain Mapping Dendrites Immunohistochemistry Microscopy, Immunoelectron Nerve Fibers, Unmyelinated Pain Physiopathology Plant Lectins Presynaptic Terminals Rats Rats, Sprague-dawley Rhizotomy Substance P Synaptic Vesicles Trpc Cation Channels Trigeminal Caudal Nucleus Trigeminal Ganglion Trigeminal Nerve Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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