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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Berson, David M. Castrucci, Ana Maria Provencio, Ignacio |
| Description | Country affiliation: United States Author Affiliation: Berson DM ( Department of Neuroscience, Brown University, Providence, Rhode Island, USA.) |
| Abstract | Melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells (ipRGCs). Melanopsin immunoreactivity reveals two dendritic plexuses within the inner plexiform layer (IPL) and morphologically heterogeneous retinal ganglion cells. Using enhanced immunohistochemistry, we provide a fuller description of murine cell types expressing melanopsin, their contribution to the plexuses of melanopsin dendrites, and mosaics formed by each type. M1 cells, corresponding to the originally described ganglion-cell photoreceptors, occupy the ganglion cell or inner nuclear layers. Their large, sparsely branched arbors (mean diameter 275 microm) monostratify at the outer limit of the OFF sublayer. M2 cells also have large, monostratified dendritic arbors (mean diameter 310 microm), but ramify in the inner third of the IPL, within the ON sublayer. There are approximately 900 M1 cells and 800 M2 cells per retina; each type comprises roughly 1-2% of all ganglion cells. The cell bodies of M1 cells are slightly smaller than those of M2 cells (mean diameters: 13 microm for M1, 15 microm for M2). Dendritic field overlap is extensive within each type (coverage factors approximately 3.8 for M1 and 4.6 for M2 cells). Rare bistratified cells deploy terminal dendrites within both melanopsin-immunoreactive plexuses. Because these are too sparsely distributed to permit complete retinal tiling, they lack a key feature of true ganglion cell types and may be anomalous hybrids of the M1 and M2 types. Finally, we observed weak melanopsin immunoreactivity in other ganglion cells, mostly with large somata, that may constitute one or more additional types of melanopsin-expressing cells. |
| File Format | HTM / HTML |
| ISSN | 00219967 |
| e-ISSN | 10969861 |
| DOI | 10.1002/cne.22381 |
| Journal | Journal of Comparative Neurology |
| Issue Number | 13 |
| Volume Number | 518 |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2010-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Neurology Retinal Ganglion Cells Cytology Metabolism Rod Opsins Animals Cell Count Cell Size Dendrites Dermoscopy Image Processing, Computer-assisted Immunoenzyme Techniques Immunohistochemistry Mice Mice, Inbred C57bl Retina Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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