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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bruinstroop, Eveline Cano, Georgina Vanderhorst, Veronique G. J. M. Cavalcante, Judney C. Wirth, Jena Sena-Esteves, Miguel Saper, Clifford B. |
| Description | Country affiliation: United States Author Affiliation: Bruinstroop E ( Department of Neurology, Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.) |
| Abstract | The pontine noradrenergic cell groups, A5, A6 (locus coeruleus), and A7, provide the only noradrenergic innervation of the spinal cord, but the individual contribution of each of these populations to the regional innervation of the spinal cord remains controversial. We used an adeno-associated viral (AAV) vector encoding green fluorescent protein under an artificial dopamine beta-hydroxylase (PRSx8) promoter to trace the spinal projections from the A5, A6, and A7 groups. Projections from all three groups travel through the spinal cord in both the lateral and ventral funiculi and in the dorsal surface of the dorsal horn, but A6 axons take predominantly the dorsal and ventral routes, whereas A5 axons take mainly a lateral and A7 axons a ventral route. The A6 group provides the densest innervation at all levels, and includes all parts of the spinal gray matter, but it is particularly dense in the dorsal horn. The A7 group provides the next most dense innervation, again including all parts of the spinal cord, but is it denser in the ventral horn. The A5 group supplies only sparse innervation to the dorsal and ventral horns and to the cervical and lumbosacral levels, but provides the densest innervation to the thoracic intermediolateral cell column, and in particular to the sympathetic preganglionic neurons. Thus, the pontine noradrenergic cell groups project in a roughly topographic and complementary fashion onto the spinal cord. The pattern of spinal projections observed suggests that the locus coeruleus might have the greatest effect on somatosensory transmission, the A7 group on motor function, and the A5 group on sympathetic function. |
| File Format | HTM / HTML |
| ISSN | 00219967 |
| e-ISSN | 10969861 |
| DOI | 10.1002/cne.23024 |
| Journal | Journal of Comparative Neurology |
| Issue Number | 9 |
| Volume Number | 520 |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-06-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Neurology Afferent Pathways Physiology Locus Coeruleus Cytology Norepinephrine Metabolism Solitary Nucleus Spinal Cord Animals Choline O-acetyltransferase Dependovirus Genetics Dopamine Beta-hydroxylase Functional Laterality Green Fluorescent Proteins Microinjections Phosphopyruvate Hydratase Phytohemagglutinins Rats, Sprague-dawley Transduction, Genetic Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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