NDLI: Serum concentrations of procalcitonin after cardiac surgery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Prat, Cristina Ricart, Pilar Ruyra, Xavier Domínguez, Josep Morillas, Jordi Blanco, Silvia Tomasa, Teresa Torres, Tomás Cámara, Luisa Molinos, Sónia Ausina, Vicente
Spatial Coverage	Spain
Description	Country affiliation: Spain Author Affiliation: Prat C ( Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. cprat.germanstrias@gencat.net)
Abstract	BACKGROUND AND AIM: Monitoring of complications in patients undergoing cardiac surgery may be difficult because cardiopulmonary bypass (CPB) can lead to a systemic inflammatory response syndrome because of exposure of blood to nonphysiological surfaces. The purpose of the study was to establish the baseline levels of procalcitonin (PCT) after cardiac surgery in our population in order to analyze a possible induction of the inflammatory response that might interfere with the diagnosis of infection by PCT. METHODS: Serum samples from patients undergoing coronary artery bypass grafting or valve replacement were collected at the time of admission to intensive care unit, after surgery as well as in the first and second postoperative days. Patients were followed for the development of postoperative complications. PCT levels were measured by immunoluminometric assay. RESULTS: The mean PCT values were significantly higher in the first postoperative day in all the groups except the control group. No increased PCT levels were found related neither to duration of CPB, nor to time of aortic clamping. Only patients who presented complications had significantly increased PCT values immediately after surgery (p = 0.004), in the first postoperative day (p < 0.0001), and in the second postoperative day (p < 0.0001) with respect to those who recovered uneventfully. CONCLUSIONS: A slight and transient increase in PCT levels was observed in the first postoperative day after cardiac surgery. Significant elevation of PCT was only observed when complications were present.
File Format	HTM / HTML
ISSN	08860440
Issue Number	6
Volume Number	23
e-ISSN	15408191
Journal	Journal of Cardiac Surgery
Language	English
Publisher	Wiley
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Cardiology Discipline Surgery Calcitonin Blood Cardiopulmonary Bypass Adverse Effects Postoperative Complications Etiology Protein Precursors Biological Markers Calcitonin Gene-related Peptide Female Humans Male Middle Aged Epidemiology Prospective Studies Roc Curve Risk Factors Sensitivity And Specificity Spain Systemic Inflammatory Response Syndrome Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine

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