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Production of biologically active Atlantic salmon interferon in transgenic potato and rice plants.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fukuzawa, Noriho Tabayashi, Noriko Okinaka, Yasushi Furusawa, Ryo Furuta, Kazuyoshi Kagaya, Uiko Matsumura, Takeshi
Description	Country affiliation: Japan Author Affiliation: Fukuzawa N ( Plant Molecular Technology Research Group, Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-1-1, Tsukisamuhigashi Toyohira-ku, Sapporo 062-8517, Japan.)
Abstract	Interferons (IFNs) are cytokines that induce an antiviral state in vertebrate cells. The Atlantic salmon (Salmo salar) IFN gene (SasaIFN-alpha1) was introduced in potato and rice plants by Agrobacterium-mediated transformation to produce a biologically active fish IFN in these plants. The transgenes and their transcripts were detected by PCR and Northern blot analysis. Western blot analysis showed the existence of SasaIFN-alpha1in transgenic plants. The antiviral activity of the SasaIFN-alpha1 protein expressed in these plants was determined by the survival rates of pre-treated cultured fish cells against pancreatic necrosis virus infection. The survival rate of cells pre-treated with transgenic samples was up to 95% but was reduced to 30-47% when cells were pre-treated with non-transgenic samples. These results demonstrated an antiviral effect of the SasaIFN-alpha1 protein derived from transgenic plants. Plant-derived IFNs may be suitable as components of functional feeds because such IFNs are free of animal pathogens and can be produced at a lower cost compared with those from transgenic mammalian and bacterial cells. This is the first study describing the production of a biologically active fish IFN using transgenic plants.
File Format	HTM / HTML
ISSN	13891723
Issue Number	2
Volume Number	110
e-ISSN	13474421
Journal	Journal of Bioscience and Bioengineering
Language	English
Publisher	Elsevier
Publisher Date	2010-08-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering Discipline Microbiology Interferon-alpha Biosynthesis Oryza Sativa Physiology Plant Proteins Plants, Genetically Modified Metabolism Protein Engineering Methods Salmo Salar Solanum Tuberosum Animals Interferons Recombinant Proteins Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Bioengineering Applied Microbiology and Biotechnology Biotechnology

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