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Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bick, Sarah L. Bick, David P. Wells, Brent E. Roesler, Mark R. Strawn, Estil Y. Lau, Eduardo C.
Description	Country affiliation: United States Author Affiliation: Bick SL ( Division of Medical Genetics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.)
Abstract	PURPOSE: To aid couples wishing to conceive children who are HLA matched to a sibling in need of a hematopoietic progenitor cell transplant, we developed a preimplantation HLA haplotype analysis of embryos that utilizes tri-, tetra-, and pentanucleotide STR markers. METHODS: For preimplantation HLA genotyping, we use polymorphic STR markers located across the HLA and flanking regions, selecting exclusively tri-, tetra-, and pentanucleotide repeats. These markers can be resolved using either capillary electrophoresis (CE) or polyacrylamide gels. RESULTS: We have developed 43 reliable STR markers for preimplantation HLA matching. Selected STR markers enabled unambiguous identification of embryos whose HLA haplotypes were matched with the affected patient using polyacrylamide gel or capillary electrophoresis. CONCLUSIONS: The use of tri-, tetra-, and pentanucleotide repeat markers and polyacrylamide gels for STR genotyping in HLA matching is a simple and cost effective approach to clinical testing.
File Format	HTM / HTML
ISSN	10580468
e-ISSN	15737330
DOI	10.1007/s10815-008-9233-2
Journal	Journal of Assisted Reproduction and Genetics
Issue Number	7
Volume Number	25
Language	English
Publisher	Springer
Publisher Date	2008-07-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Reproductive Medicine Discipline Genectics Embryo Implantation Hla Antigens Genetics Haplotypes Hematopoietic Stem Cells Cytology Nucleotides Chemistry Cell Transplantation Electrophoresis, Capillary Electrophoresis, Polyacrylamide Gel Genetic Markers Genotype Microsatellite Repeats Preimplantation Diagnosis
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology

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