NDLI: Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.

Please wait, while we are loading the content...

Caudal bupivacaine supplemented with morphine or clonidine, or supplemented with morphine plus clonidine in children undergoing infra-umbilical urological and genital procedures: a prospective, randomized and double-blind study.

Total spinal block after spinal anesthesia following ongoing epidural analgesia for cesarean delivery.

Difficult tracheal intubation using the Airway Scope in a patient with unexpected mouth-opening difficulty.

Addition of a video camera system improves the ease of Airtraq(®) tracheal intubation during chest compression.

Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery.

Spinal anesthesia for cesarean section in a patient with chronic inflammatory demyelinating polyradiculoneuropathy.

Landiolol attenuates cardiovascular response at induction of general anesthesia for cesarean delivery.

Use of tranexamic acid in pediatric cardiac surgery: we really need more.

Anesthetic management of Prader-Willi syndrome: what if neuromuscular relaxants could not be avoided?

Reversal of neuromuscular blockade with sugammadex in a patient with spinal muscular atrophy type III (Kugelberg-Welander syndrome).

A high dose of dexmedetomidine using the BIS monitor™ for diagnostic and interventional cardiac catheterization in a toddler with congenital heart disease.

Use of GlideScope in airway management of a patient with osteogenesis imperfecta.

Changes of motor evoked potentials during descending thoracic and thoracoabdominal aortic surgery with deep hypothermic circulatory arrest.

Percutaneous electrode placement for spinal cord stimulation in a patient with spinal fusion: a technical report.

Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass.

Hypothermic cardiopulmonary bypass for minimally invasive mitral valve plasty in adult moyamoya disease.

Regional anesthesia with a single spinal anesthesia using hyperbaric bupivacaine in a child with arthroglyposis multiplex congenita.

Improvement of motor evoked potentials monitoring is required during thoracic or thoracoabdominal aortic aneurysm surgery under hypothermic cardiopulmonary bypass.

Suspicion of duplicate publication regarding 'J Anesth 2011; 25:953-4'.

Year: 2012 Volume: 26 Issue: 1

Year: 2011 Volume: 25

Year: 2010 Volume: 24

Year: 2009 Volume: 23

Year: 2008 Volume: 22

Year: 1997 Volume: 11

Year: 1996 Volume: 10

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wei, Xin Wei, Wei
Description	Author Affiliation: Wei X ( Department of Anesthesiology, Anhui Medical University Affiliated Auhui Provincial Hospital, 230001 Hefei, People's Republic of China.)
Abstract	PURPOSE: This study was undertaken to examine the effect of gabapentin for preventing hyperalgesia induced by morphine and fentanyl withdrawal in rats. METHODS: To induce hyperalgesia, Sprague Dawley (SD) rats were subcutaneously injected with fentanyl four times at 15-min intervals (60 µg/kg per injection), resulting in total dose of 240 µg/kg over 1 h, and morphine 10 mg/kg twice daily for 7 days. The effect of gabapentin was detected with behavioral tail-flick and paw-withdrawal tests. RESULTS: Drug termination produced significant decrease in antinociception thresholds (P < 0.05 vs. saline group), indicating that the rats became sensitive to thermal stimuli. In rats that received combined treatment with fentanyl/morphine and gabapentin (25/50 mg/kg), results demonstrated that there were no significant decreases in antinociception thresholds (vs. saline group) after opioid withdrawal. Gabapentin (50 mg/kg) could also prevent morphine tolerance. The 50% effective dose (ED50) value was 12.5 mg/kg in tail-flick and 13.6 mg/kg in paw-withdrawal tests. CONCLUSIONS: The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH.
File Format	HTM / HTML
ISSN	09138668
Issue Number	2
Volume Number	26
e-ISSN	14388359
Journal	Journal of Anesthesia
Language	English
Publisher	Springer
Publisher Date	2012-04-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology Amines Pharmacology Chronic Pain Drug Therapy Cyclohexanecarboxylic Acids Fentanyl Adverse Effects Hyperalgesia Prevention & Control Morphine Substance Withdrawal Syndrome Gamma-aminobutyric Acid Analgesics, Opioid Animals Drug Tolerance Chemically Induced Male Pain Measurement Drug Effects Pain Threshold Rats Rats, Sprague-dawley Journal Article
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.

The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats.

Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents.

Gabapentin may cause reversible visual field constriction.

Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin

Gabapentin and opioid craving.

The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.

Gabapentin-induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain.

Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats.

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.

Similar Documents

The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.

The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats.

Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents.

Gabapentin may cause reversible visual field constriction.

Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin

Gabapentin and opioid craving.

The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.

Gabapentin-induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain.

Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats.

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.