NDLI: Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block for open retropubic prostatectomy.

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Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block for open retropubic prostatectomy.

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Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block for open retropubic prostatectomy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kitayama, Masato Wada, Morito Hashimoto, Hiroshi Kudo, Tsuyoshi Yakoshi, Chihiro Hirota, Kazuyoshi
Description	Author Affiliation: Kitayama M ( Department of Anesthesiology, Hirosaki University Medicine Hospital, Hirosaki, Japan, masakita@cup.ocn.ne.jp.)
Abstract	PURPOSE: Ropivacaine-induced vasoconstriction may affect the early absorption speed of ropivacaine; however, the effects of dose on pharmacokinetics following transversus abdominis plane (TAP) block have not been studied. In this study, we have examined plasma ropivacaine concentrations following TAP block with various ropivacaine concentrations (0.25, 0.5, and 0.75 %). METHODS: With the approval of our University ethics committee and informed consent, 39 adult patients undergoing open retropubic prostatectomy were enrolled. Patients were randomly assigned to three groups (n = 13 each) receiving TAP block with 20 ml (10 ml each side) of different concentrations of ropivacaine. To determine plasma concentrations, blood samples were drawn before and 15, 30, 45, 60, 90, 120, and 180 min after completion of bilateral TAP blocks. Plasma ropivacaine concentrations were analyzed by gas chromatography with mass spectrometry. RESULTS: We found that the peak plasma concentrations (C(max)) increased dose dependently (0.41 ± 0.14, 0.89 ± 0.55, and 1.56 ± 0.50 µg/ml), but the times to C(max) (23.0 ± 15.8, 23.1 ± 14.5, and 20.8 ± 11.5 min) were not different between 0.25, 0.5, and 0.75 % ropivacaine doses, respectively. Terminal elimination half-life (t(1/2)), total body clearance (CL), and distribution volume (V(d)) were also not different among the three groups. CONCLUSION: Ropivacaine concentration did not alter pharmacokinetic profile following TAP blocks.
File Format	HTM / HTML
ISSN	09138668
Issue Number	4
Volume Number	28
e-ISSN	14388359
Journal	Journal of Anesthesia
Language	English
Publisher	Springer
Publisher Date	2014-08-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology Abdominal Muscles Amides Pharmacokinetics Anesthetics, Local Nerve Block Methods Prostatectomy Ultrasonography, Interventional Aged Administration & Dosage Blood Dose-response Relationship, Drug Half-life Humans Male Middle Aged Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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