NDLI: Activation of NK cells by HIV-specific ADCC antibodies: role for granulocytes in expressing HIV-1 peptide epitopes.

Please wait, while we are loading the content...

Immunogenicity, protective efficacy and safety of a recombinant DNA vaccine encoding truncated Plasmodium yoelii sporozoite asparagine-rich protein 1 (PySAP1).

Tolerogenic vaccines for Multiple sclerosis.

Targeting antitumor CD4 helper T cells with universal tumor-reactive helper peptides derived from telomerase for cancer vaccine.

Economics of vaccines revisited.

High proportions of regulatory B and T cells are associated with decreased cellular responses to pH1N1 influenza vaccine in HIV-infected children and youth (IMPAACT P1088)

Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation.

Improving adherence rates to a cocooning program: a pilot experience in Italy.

Current status of immunotherapy for the treatment of biliary tract cancer.

Economic analysis of the first 20 years of universal hepatitis B vaccination program in Italy: an a posteriori evaluation and forecast of future benefits.

Epidemiology of tick-borne encephalitis (TBE) in Europe and its prevention by available vaccines.

Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization.

The controversy over H5N1 transmissibility research: An opportunity to define a practical response to a global threat

Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits.

Listeriolysin O as a strong immunogenic molecule for the development of new anti-tumor vaccines.

Vitamin D and influenza vaccination. (Part 2)

Cost-effectiveness of vaccination against meningococcal B among Dutch infants: Crucial impact of changes in incidence.

Prospects for prophylactic hepatitis C vaccines based on virus-like particles.

Successes, failures and new perspectives of idiotypic vaccination for B-cell non-Hodgkin lymphomas.

Vitamin D and influenza vaccination. (Part 1)

Clinical evaluation of therapeutic cancer vaccines.

Low immunogenicity predicted for emerging avian-origin H7N9: Implication for influenza vaccine design

Letter from the Editor

Portrait: coincidences, convergences and opportunities.

Year: 2013 Volume: 9 Issue: 4

Year: 2013 Volume: 9 Issue: 3

Year: 2013 Volume: 9 Issue: 2

Year: 2013 Volume: 9 Issue: 1

Year: 2012 Volume: 8

Activation of NK cells by HIV-specific ADCC antibodies: role for granulocytes in expressing HIV-1 peptide epitopes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Madhavi, Vijaya Navis, Marjon Chung, Amy W. Isitman, Gamze Wren, Leia H. De Rose, Robert Kent, Stephen J. Stratov, Ivan
Description	Author Affiliation: Madhavi V ( Department of Microbiology and Immunology)
Abstract	HIV-specific ADCC antibodies could play a role in providing protective immunity. We have developed a whole blood ADCC assay that measures NK cell activation in response to HIV peptide epitopes. These HIV peptide-specific ADCC responses are associated with escape from immune recognition and slower progression of HIV infection and represent interesting HIV vaccine antigens. However, the mechanism by which these epitopes are expressed and whether or not they induce NK-mediated killing of cells expressing such peptide-antigens is not understood. Herein, we show that fluorescent-tagged ADCC peptide epitopes associate with blood granulocytes. The peptide-associated granulocytes become a specific target for antibody-mediated killing, as shown by enhanced expression of apoptosis marker Annexin and reduction in cell numbers. When HIV Envelope gp140 protein is utilized in the ADCC assay, we detected binding to its ligand, CD4. During the incubation, cells co-expressing gp140 and CD4 reduce in number. We also detected increasing Annexin expression in these cells. These data indicate that blood cells expressing HIV-specific ADCC epitopes are targeted for killing by NK cells in the presence of ADCC antibodies in HIV+ plasma and provide a clearer framework to evaluate these antigens as vaccine candidates.
File Format	HTM / HTML
ISSN	21645515
e-ISSN	2164554X
DOI	10.4161/hv.23446
Journal	Human Vaccines & Immunotherapeutics
Issue Number	5
Volume Number	9
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Therapeutics Antibody-dependent Cell Cytotoxicity Antigen-presenting Cells Immunology Granulocytes Hiv Antibodies Hiv-1 Killer Cells, Natural Cells, Cultured Hiv Antigens Metabolism Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity

Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure.

Anti-HIV antibody-dependent activation of NK cells impairs NKp46 expression.

Activation of NK cells by ADCC antibodies and HIV disease progression.

Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells

Non-Genetically Improving the Natural Cytotoxicity of Natural Killer (NK) Cells

Natural Killer (NK) Cell Expression of CD2 as a Predictor of Serial Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

MHC-unrestricted lysis of MUC1-expressing cells by human peripheral blood mononuclear cells.

Can HIV-1-Specific ADCC Assist the Clearance of Reactivated Latently Infected Cells?

Activation of NK cells by HIV-specific ADCC antibodies: role for granulocytes in expressing HIV-1 peptide epitopes.

Similar Documents

Natural Killer (NK) Cell Education Differentially Influences HIV Antibody-Dependent NK Cell Activation and Antibody-Dependent Cellular Cytotoxicity

Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure.

Anti-HIV antibody-dependent activation of NK cells impairs NKp46 expression.

Activation of NK cells by ADCC antibodies and HIV disease progression.

Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells

Non-Genetically Improving the Natural Cytotoxicity of Natural Killer (NK) Cells

Natural Killer (NK) Cell Expression of CD2 as a Predictor of Serial Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

MHC-unrestricted lysis of MUC1-expressing cells by human peripheral blood mononuclear cells.

Can HIV-1-Specific ADCC Assist the Clearance of Reactivated Latently Infected Cells?

Activation of NK cells by HIV-specific ADCC antibodies: role for granulocytes in expressing HIV-1 peptide epitopes.