NDLI: Reduced MyD88 dependency of ISCOMATRIX™ adjuvant in a DNA prime-protein boost HIV vaccine.

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Reduced MyD88 dependency of ISCOMATRIX™ adjuvant in a DNA prime-protein boost HIV vaccine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buglione-Corbett, Rachel Pouliot, Kimberly Marty-Roix, Robyn Li, Wei West, Kim Wang, Shixia Morelli, Adriana Baz Lien, Egil Lu, Shan
Description	Author Affiliation: Buglione-Corbett R ( Department of Medicine); Pouliot K ( Department of Medicine); Marty-Roix R ( Department of Medicine); Li W ( Department of Medicine); West K ( Department of Medicine); Wang S ( Department of Medicine); Morelli AB ( CSL Limited, Parkville, VIC Australia.); Lien E ( Department of Medicine); Lu S ( Department of Medicine)
Abstract	ISCOMATRIX™ adjuvant is an integrated adjuvant system due to its ability to both facilitate antigen delivery and immunomodulate the innate and adaptive immune responses to vaccination. ISCOMATRIX™ adjuvant strongly induces both humoral and cell-mediated immunity in formulation with a range of antigens in pre-clinical and clinical evaluations. In this study, we describe the adaptive and innate immune responses associated with ISCOMATRIX™ adjuvant in the context of a previously described HIV-1 vaccine, DP6-001. The DP6-001 vaccine consists of a unique pentavalent HIV-1 Env DNA prime-protein boost regimen. This study demonstrates the potent induction of vaccine-specific antibodies in a mouse model, as well as broadly neutralizing antibodies in immunized rabbits. In addition, we identify a potentially critical role for DNA priming in the induction of the vaccine-specific immune response as well as the serum cytokine profiles associated with ISCOMATRIX™ adjuvant. Most interestingly, DNA prime immunizations made ISCOMATRIX™ adjuvant less dependent on the central innate immune adaptor MyD88, revealing a previously unknown mechanism that may expand our knowledge on the use of adjuvants.
File Format	HTM / HTML
ISSN	21645515
e-ISSN	2164554X
Journal	Human Vaccines & Immunotherapeutics
Issue Number	4
Volume Number	10
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Therapeutics Aids Vaccines Administration & Dosage Immunology Adjuvants, Immunologic Cholesterol Immunization Myeloid Differentiation Factor 88 Metabolism Phospholipids Saponins Animals Antibodies, Neutralizing Blood Cytokines Drug Combinations Hiv Antibodies Hiv-1 Mice Mice, Inbred Balb C Mice, Inbred C57bl Rabbits Vaccines, Dna Vaccines, Subunit Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology

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