NDLI: Further efforts in the achievement of congenital rubella syndrome/rubella elimination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cozza, Vanessa Martinelli, Domenico Cappelli, Maria Giovanna Tafuri, Silvio Fortunato, Francesca Prato, Rosa
Spatial Coverage	Italy
Description	Country affiliation: Italy Author Affiliation: Cozza V ( a Department of Medical and Surgical Sciences, University of Foggia)
Abstract	The Italian National Plan of Measles and Rubella Elimination 2010-2015 has deferred the objective to reduce congenital rubella syndrome (CRS) to <1 case per 100 000 live births to 2015 and has highlighted the need to reduce to <5% susceptibility to rubella among women in childbearing-age. In Puglia region, MMR vaccine coverage is 93% in newborns (cohort 2010; one dose), 85% in children 5-6 years old and 77% in adolescents (cohort 2005 and 1997, respectively; two doses). Combining available seroepidemiological data and results of a survey on the attitude towards rubella vaccination and rubella testing before pregnancy, we could estimate that 5.7% of Apulian women in childbearing-age are currently susceptible to rubella infection. The regional infectious disease routine notification system reported no cases of CRS and rubella in pregnancy in 2001-2010 period. The inconsistency among the mentioned data triggered the evaluation of the reliability of disease reporting. We performed a retrospective case-finding for the years 2003-2011. We scanned the regional hospital discharge registry to identify hospitalizations for rubella in pregnancy and CRS and retrieve individual records. We also searched for clinical history of CRS mothers in the delivery assistance certificate registry. We identified one CRS, two confirmed and four suspected congenital infections, and seven cases of rubella in pregnancy. Passive surveillance of CRS and rubella in pregnancy appears not to be reliable in the light of strengthening rubella elimination strategies.
File Format	HTM / HTML
ISSN	21645515
e-ISSN	2164554X
DOI	10.4161/hv.36154
Journal	Human Vaccines & Immunotherapeutics
Issue Number	1
Volume Number	11
Language	English
Publisher	Taylor & Francis
Publisher Date	2015-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Discipline Therapeutics Rubella Syndrome, Congenital Epidemiology Prevention & Control Rubella Adolescent Child, Preschool Disease Susceptibility Epidemiological Monitoring Health Policy Immunization Programs Infant, Newborn Pregnancy Retrospective Studies
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology

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