NDLI: Is there a 'margin' for error in pancreatic cancer surgery?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Frampton, Adam E. Gall, Tamara M. H. Krell, Jonathan Ahmad, Raida Jiao, Long R.
Description	Country affiliation: United kingdom Author Affiliation: Frampton AE ( HPB Surgical Unit, Department of Surgery & Cancer, Imperial College, Hammersmith Hospital campus, Du Cane Road, London, W12 0HS, UK.)
Abstract	Evaluation of: Gnerlich JL, Luka SR, Deshpande AD et al. Microscopic margins and patterns of treatment failure in resected pancreatic adenocarcinoma. Arch. Surg. 147(8), 753-760 (2012). Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with one of the worst 5-year survival rates of any malignancy. Even after potentially curative surgical resection, disease may progress rapidly. It is therefore important to identify clinicopathologic factors that influence survival and may be modified to improve outcomes. The evaluated article presents data from a retrospective review of patients who underwent surgical resection for PDAC. Local recurrence (LR), distant recurrence and survival were compared between patients with a negative resection margin (R0) and those with a positive resection margin (R1). Patients with R1 posterior margins, in particular, were more likely to have LR and worse LR-free survival. In addition, this was more pronounced if patients had lymph-node involvement. Similar results have been reported in other studies and this study illustrates that standardized pathological reporting of PDAC specimens may allow further investigation of factors affecting R1 patients.
File Format	HTM / HTML
ISSN	14796694
Issue Number	1
Journal	Future Oncology
Volume Number	9
e-ISSN	17448301
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2013-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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