NDLI: Circulating biomarker panels for targeted therapy in brain tumors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tanase, Cristiana Albulescu, Radu Codrici, Elena Popescu, Ionela Daniela Mihai, Simona Enciu, Ana Maria Cruceru, Maria Linda Popa, Adrian Claudiu Neagu, Ana Iulia Necula, Laura Georgiana Mambet, Cristina Neagu, Monica
Description	Country affiliation: Romania Author Affiliation: Tanase C ( Victor Babes National Institute of Pathology, Biochemistry-Proteomics Department, no 99-101 Splaiul Independentei, 050096 Sector 5 Bucharest, Romania.)
Abstract	An important goal of oncology is the development of cancer risk-identifier biomarkers that aid early detection and target therapy. High-throughput profiling represents a major concern for cancer research, including brain tumors. A promising approach for efficacious monitoring of disease progression and therapy could be circulating biomarker panels using molecular proteomic patterns. Tailoring treatment by targeting specific protein-protein interactions and signaling networks, microRNA and cancer stem cell signaling in accordance with tumor phenotype or patient clustering based on biomarker panels represents the future of personalized medicine for brain tumors. Gathering current data regarding biomarker candidates, we address the major challenges surrounding the biomarker field of this devastating tumor type, exploring potential perspectives for the development of more effective predictive biomarker panels.
File Format	HTM / HTML
ISSN	14796694
Issue Number	3
Volume Number	11
e-ISSN	17448301
Journal	Future Oncology
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Antineoplastic Agents Therapeutic Use Brain Neoplasms Diagnosis Drug Therapy Molecular Targeted Therapy Biological Markers Blood Metabolism Tumor Markers, Biological Genetics Humans Micrornas Neoplastic Cells, Circulating Neoplastic Stem Cells Drug Effects Proteome Proteomics Signal Transduction Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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