NDLI: Hedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Piérard-Franchimont, Claudine Hermanns-Lê, Trinh Paquet, Philippe Herfs, Michael Delvenne, Philippe Piérard, Gérald E.
Description	Country affiliation: Belgium Author Affiliation: Piérard-Franchimont C ( Laboratory of Skin Bioengineering & Imaging (LABIC), Department of Clinical Sciences, University of Liège, Belgium.); Hermanns-Lê T ( Department of Dermatopathology, Unilab Lg, Liège University Hospital, Liège, Belgium.); Paquet P ( Department of Dermatopathology, Unilab Lg, Liège University Hospital, Liège, Belgium.); Herfs M ( Department of Dermatopathology, Unilab Lg, Liège University Hospital, Liège, Belgium.); Delvenne P ( Laboratory of Experimental Pathology, Liège University Hospital, Liège, Belgium.); Piérard GE ( Department of Dermatopathology, Unilab Lg, Liège University Hospital, Liège, Belgium.)
Abstract	Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in PTCH1 or smoothened, two conducting proteins of the Hedgehog pathway. They rarely progress deeply and metastasize; however, if they do, these advanced basal cell carcinoma become amenable to treatment by inhibiting the Hedgehog and the P13K-mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development.
File Format	HTM / HTML
ISSN	14796694
Issue Number	22
Volume Number	11
e-ISSN	17448301
Journal	Future Oncology
Language	English
Publisher	Future Medicine Ltd.
Publisher Date	2015-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Basal Cell Drug Therapy Hedgehog Proteins Antagonists & Inhibitors Molecular Targeted Therapy Skin Neoplasms Tor Serine-threonine Kinases Anilides Pharmacology Therapeutic Use Metabolism Pathology Drug Resistance, Neoplasm Everolimus Humans Itraconazole Neoplasm Staging Phosphatidylinositol 3-kinases Pyridines Receptors, G-protein-coupled Signal Transduction Drug Effects Veratrum Alkaloids Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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