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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdel-Naser, M. Badawy Zouboulis, C. C. |
| Description | Country affiliation: Germany Author Affiliation: Abdel-Naser MB ( Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg 38, 06847 Dessau, Germany.) |
| Abstract | Clindamycin phosphate 1.2% together with tretinoin 0.025% as a gel (CTG) is a topical formulation of a fixed and stable combination approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. The main indication of CTG is the management of moderate comedonal and mild-to-moderate papulopustular acne, an acne form which is present in more than 50% of acne patients. CTG can also be combined with systemic antiacne therapy, such as systemic isotretinoin, in nodulocystic acne. The product combines the anti-inflammatory and antibacterial properties of clindamycin with the well proven and beneficial comedolytic and anticomedogenic effects of tretinoin (all-trans retinoic acid). The addition of clindamycin to tretinoin enhances the comedolytic efficacy of tretinoin in moderate-to-severe acne of the face. The comedolytic activity of tretinoin and the anti-inflammatory efficacy of clindamycin accelerate resolution of all types of acne lesions without affecting the safety of both compounds. Discontinuation rates due to adverse events related to this formulation were found to be low ( |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 16 |
| Volume Number | 9 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2008-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Acne Vulgaris Drug Therapy Clindamycin Analogs & Derivatives Tretinoin Therapeutic Use Pharmacology Dosage Forms Gels Humans Treatment Outcome Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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