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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Guarino, Elisa Nigi, Laura Patti, Aurora Fondelli, Cecilia Dotta, Francesco |
| Description | Country affiliation: Italy Author Affiliation: Guarino E ( University of Siena, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, Diabetes Unit, Policlinico Le Scotte, 3° Lotto - 5S, Viale Bracci 18, 53100 Siena, Italy.) |
| Abstract | INTRODUCTION: Type 2 diabetes mellitus (T2DM) is pathophysiologically characterized by a combination of insulin resistance and beta-cell dysfunction. Consequently, a proper treatment of such a disease should target both of these defects. Dipeptidyl peptidase-4 (DPP-4) inhibitors are among the most recent additions to the therapeutic options for T2DM and are able to increase circulating levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thus stimulating glucose-dependent insulin secretion. AREAS COVERED: This paper provides an overview of the clinical results of combination therapy with metformin and the DPP-4 inhibitor vildagliptin in T2DM patients. EXPERT OPINION: Vildagliptin-metformin single-tablet combination is indicated for the treatment of T2DM patients not achieving a sufficient glycemic control at their maximally tolerated dose of metformin. Results from clinical trials provide evidence of vildagliptin efficacy administered in addition to metformin, as either first- or second-line treatment. The vildagliptin-metformin association seems to have favorable effects on beta-cell function and is characterized by good safety and tolerability profiles when compared with other antidiabetic agents. Of note, data available suggest that administration of fixed-dose combination products, together with the low incidence of adverse gastrointestinal events, may improve compliance and adherence of patients to therapy, resulting in an improved metabolic control. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 9 |
| Volume Number | 13 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Adamantane Analogs & Derivatives Diabetes Mellitus, Type 2 Drug Therapy Dipeptidyl-peptidase Iv Inhibitors Therapeutic Use Hypoglycemic Agents Metformin Nitriles Pyrrolidines Administration & Dosage Adverse Effects Administration, Oral Blood Glucose Drug Effects Metabolism Blood Physiopathology Drug Combinations Evidence-based Medicine Humans Insulin Insulin Resistance Insulin-secreting Cells Tablets Treatment Outcome Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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