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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Stoltey, Juliet E. Barry, Pennan M. |
| Description | Country affiliation: United States Author Affiliation: Stoltey JE ( San Francisco Department of Public Health STD Prevention and Control Services, University of California-San Francisco, Division of Infectious Diseases, 513 Parnassus Avenue, Box 0654, San Francisco, CA 94143, USA. juliet.stoltey@ucsf.edu) |
| Abstract | INTRODUCTION: Over the last several years, Neisseria gonorrhoeae has developed decreased susceptibility to extended-spectrum cephalosporins worldwide. Gonococcal antimicrobial surveillance programs in multiple regions have documented the rise in N. gonorrhoeae isolates' minimum inhibitory concentrations to cephalosporins, and the first cases of ceftriaxone treatment failure have been reported. These developments have prompted the use of the term 'superbug' and concerns about the emergence of untreatable gonococcal infections. AREAS COVERED: Since the publication of the last detailed review of the use of cephalosporins for gonorrhea in 2009, several new developments have occurred, which are detailed in this review. A variety of treatment strategies have been proposed in response to this 'superbug' threat, including increasing the dose or providing multiple doses of cephalosporins, multidrug therapy, rotating therapeutic regimens and individualized treatment based on susceptibility testing. EXPERT OPINION: A robust public health response is needed that includes better diagnosis and treatment of pharyngeal gonorrhea, improved surveillance of antimicrobial resistance, informed treatment approaches and reduction of the global burden of gonococcal infections. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| e-ISSN | 17447666 |
| DOI | 10.1517/14656566.2012.690396 |
| Journal | Expert Opinion on Pharmacotherapy |
| Issue Number | 10 |
| Volume Number | 13 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Pharmacology Anti-bacterial Agents Therapeutic Use Cephalosporins Gonorrhea Drug Therapy Drug Resistance, Bacterial Population Surveillance Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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