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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Makris, Michael Maurer, Marcus Zuberbier, Torsten |
| Description | Country affiliation: Greece Author Affiliation: Makris M ( University of Athens, 'Attikon' University Hospital, Medical School, 2nd Department of Dermatology and Venereology, Allergy Unit 'D. Kalogeromitros' , Athens , Greece torsten.zuberbier@charite.de.) |
| Abstract | INTRODUCTION: Urticaria, by definition, is a disease presenting with wheals, angioedema or both. In patients with recurrent angioedema without wheals, urticaria needs to be distinguished from bradykinin-mediated angioedema, for example, hereditary angioedema or ACE inhibitor-induced angioedema. AREAS COVERED: Urticaria is comprised of acute and chronic forms. The latter group of chronic urticaria has many different subtypes needing partly different therapeutic approaches. However, all therapeutic approaches for symptomatic treatment center on reducing mast cell-mediator-release and preventing its effect. EXPERT OPINION: The current guidelines recommend non-sedating, second generation H1-antihistamines (nsAHs) as the first-line treatment. If needed, nsAHs are to be used at higher doses (up to fourfold the standard dose), and Omalizumab, Montelukast or Cyclosporin A (not in preferred order) are recommended as third-line options. Many alternative treatments have been reported but not tested in randomized controlled trials. These include among others dapsone, H2-antihistamines, anticoagulants and methotrexate. Some therapies should no longer be used according to current guidelines, since studies have shown their inefficacy or because new safety concerns have emerged. This mainly refers to the formally propagated use of sedating antihistamines at night, which change REM-sleeping-patterns and learning curves and have been shown in head-to-head trials to not be superior in efficacy to non-sedating antihistamines. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 18 |
| Volume Number | 14 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Acetates Therapeutic Use Antibodies, Anti-idiotypic Antibodies, Monoclonal, Humanized Cyclosporine Histamine H1 Antagonists Histamine Release Drug Effects Quinolines Urticaria Drug Therapy Administration & Dosage Chronic Disease Dose-response Relationship, Drug Drug Therapy, Combination Humans Omalizumab Practice Guidelines As Topic Treatment Outcome Etiology Immunology Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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