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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wan, Hoyee AlHarbi, Bader Murshed Macdonald, Robert Loughlin |
| Description | Country affiliation: Canada Author Affiliation: Wan H ( University of Toronto, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Division of Neurosurgery, Department of Surgery , Toronto, Ontario, M5B 1W8 , Canada.) |
| Abstract | INTRODUCTION: Subarachnoid hemorrhage (SAH) patients often develop brain injury as a result of a number of delayed complications, resulting in significant morbidity and mortality. Many of these complications arise due to delayed cerebral ischemia, which occurs secondary to the hemorrhage. AREAS COVERED: The mechanisms of the delayed injury are reviewed, including angiographic vasospasm, cortical spreading ischemia, small arteriolar constriction, microthromboemboli, free radical injury and inflammation. Some current and prospective therapies for SAH are discussed, in the context of these complications. Statins have been particularly promising in experimental studies. EXPERT OPINION: Multiple mechanisms are involved in the pathogenesis of the delayed insult after SAH. New drugs may need to target multiple pathways to injury. Trials aiming to treat complications after SAH could benefit from taking into account the multifactorial pathogenesis of delayed insults. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 2 |
| Volume Number | 15 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2014-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Brain Ischemia Etiology Intracranial Aneurysm Complications Subarachnoid Hemorrhage Animals Brain Injuries Pathology Drug Design Humans Hydroxymethylglutaryl-coa Reductase Inhibitors Therapeutic Use Therapy Molecular Targeted Therapy Time Factors Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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