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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Austreid, Eilin Lonning, Per Eystein Eikesdal, Hans Petter |
| Description | Country affiliation: Norway Author Affiliation: Austreid E ( University of Bergen, Department of Clinical Science, Section of Oncology , Bergen , Norway.) |
| Abstract | INTRODUCTION: Deregulated signaling pathways are associated with resistance to chemotherapy and endocrine treatment, providing a rationale for the implementation of novel targeted therapies in breast cancer therapy. Key molecules targeted therapeutically in ongoing clinical breast cancer trials are phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (mTOR), Src, insulin-like growth factor 1 receptor, heat shock protein-90, histone deacetylases, cyclin-dependent kinases (CDKs), Notch and human epidermal growth factor receptors (HERs). AREAS COVERED: This review provides an overview of novel targeted agents currently explored in clinical breast cancer trials and registered in ClinicalTrials.gov. The main focus will be on their ability to prevent or reverse endocrine resistance and chemoresistance in breast cancer. EXPERT OPINION: HER2 targeted agents have extended survival substantially, both in the adjuvant and metastatic setting, pointing to a crucial dependency on this pathway in HER2-amplified breast cancer, including drug resistance reversal. While data on mTOR inhibitors are encouraging and preliminary results on CDK4/6 and Src inhibitors exciting, so far other targeted agents have been of limited benefit when added in concert with conventional therapies. Future clinical trials should systematically explore biomarkers and defects in functional gene cascades to identify relevant biological mechanisms to be targeted therapeutically in breast cancer. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 5 |
| Volume Number | 15 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2014-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antineoplastic Agents Therapeutic Use Breast Neoplasms Drug Therapy Drug Resistance, Neoplasm Molecular Targeted Therapy Receptor, Erbb-2 Metabolism Animals Antineoplastic Agents, Hormonal Antineoplastic Combined Chemotherapy Protocols Clinical Trials As Topic Drug Therapy, Combination Female Humans Phosphatidylinositol 3-kinases Proto-oncogene Proteins C-akt Antagonists & Inhibitors Receptors, Estrogen Signal Transduction Tor Serine-threonine Kinases Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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