NDLI: A comparison of progestogens or oral contraceptives and gonadotropin-releasing hormone agonists for the treatment of endometriosis: a systematic review.

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A comparison of progestogens or oral contraceptives and gonadotropin-releasing hormone agonists for the treatment of endometriosis: a systematic review.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jeng, Cherng-Jye Chuang, Linus Shen, Jenta
Description	Author Affiliation: Jeng CJ ( Kaohsiung Medical University, Kaohsiung Medical University Hospital, School of Medicine, College of Medicine, Department of Obstetrics and Gynecology , No.100, Ziyou 1st Rd., Kaohsiung 80010 , Taiwan +886 937027466 )
Abstract	OBJECTIVE: This systematic review examined the use of progestogens or oral contraceptives and gonadotropin-releasing hormone (GnRH) agonists for the treatment of endometriosis. RESEARCH DESIGN AND METHODS: Inclusion criteria were: i) randomized controlled trials (RCTs); ii) comparison of progestogens with GnRH agonists for treatment of endometriosis; and iii) endometriosis diagnosed by laparoscopy or laparotomy. MAIN OUTCOME MEASURES: Pelvic pain, bone mineral density, serum estradiol level, and side effects. RESULTS: Of 128 articles identified, there were four RCTs comparing the use of progestogens and GnRH agonists. In three studies a progestogen (gestrinone, lynestrenol, or dienogest) was compared with leuprolide. In one study, ethinyl estradiol/norethindrone was compared with leuprolide/norethindrone. A meta-analysis was not possible as the studies varied markedly in their protocols, inclusion criteria, and the drugs and doses administered. Leuprolide was as effective as gestrinone, dienogest, and continuous oral contraceptives (OCs) for the relief of endometriosis-related pain, whereas it was superior to lynestrenol. Leuprolide was associated with a significant reduction in bone mineral density and estradiol levels and a higher incidence of hot flushes, headaches, mood changes, and vaginal dryness, whereas progestogens were associated with higher incidences of weight gain and acne. CONCLUSIONS: These results suggest that progestogens or OCs may be used as first-line therapy for endometriosis.
File Format	HTM / HTML
ISSN	14656566
Issue Number	6
Volume Number	15
e-ISSN	17447666
Journal	Expert Opinion on Pharmacotherapy
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Contraceptives, Oral Therapeutic Use Endometriosis Drug Therapy Gonadotropin-releasing Hormone Agonists Progestins Female Humans Randomized Controlled Trials As Topic Comparative Study Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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