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Iontophoretic transdermal fentanyl for the management of acute perioperative pain in hospitalized patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fanelli, Andrea Sorella, Maria Cristina Chelly, Jacques E.
Description	Country affiliation: Italy Author Affiliation: Fanelli A ( a Department of Medical and Surgical Sciences , Anesthesia and Intensive Care Unit, Policlinico S. Orsola-Malpighi , Bologna , Italy.); Sorella MC ( a Department of Medical and Surgical Sciences , Anesthesia and Intensive Care Unit, Policlinico S. Orsola-Malpighi , Bologna , Italy.); Chelly JE ( b Division of Acute Interventional Perioperative Pain and Regional Anesthesia, Department of Anesthesiology , University of Pittsburgh Medical Center Presbyterian-Shadyside Hospitals , Pittsburgh , PA , USA.)
Abstract	INTRODUCTION: Intravenous (I.V.) morphine administered through a patient-controlled system currently represents the gold standard treatment for moderate to severe acute postoperative pain. To fix the limitations showed by the available I.V. patient-controlled analgesia (PCA) systems that may restrict its use in the clinical practice a needle-free, iontophoretic, fentanyl patient-controlled transdermal system has been developed and recently approved by the United States Food and Drug Administration (FDA) and by the European Medicines Agency (EMA). AREAS COVERED: This review aims at describing the technology, pharmacology and clinical efficacy of fentanyl iontophoretic transdermal system (ITS) in the treatment of acute pain. A literature search was conducted in the PUBMED database using the term 'fentanyl iontophoretic transdermal system' through September 2015 and results from the main clinical trials are discussed. EXPERT OPINION: In 2015, the appropriate treatment of acute pain after surgery is still a challenge and it represents a primary goal in the care of the surgical patient. When regional analgesia techniques are not applicable and systemic analgesia is required, patient controlled systems represent the standard of care for opioid administration. The fentanyl ITS presents several potential advantages compared to the currently used PCA devices. In particular, it does not require intravenous lines and eliminates the potential for drug administration errors, observed with manually programmed standard PCA devices. Nevertheless, further studies are needed to address eventual inter-individual variability especially for opioid tolerant patients.
File Format	HTM / HTML
ISSN	14656566
Issue Number	4
Volume Number	17
e-ISSN	17447666
Journal	Expert Opinion on Pharmacotherapy
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Analgesics, Opioid Administration & Dosage Fentanyl Pain Management Pain, Postoperative Drug Therapy Acute Pain Administration, Cutaneous Analgesia, Patient-controlled Pharmacokinetics Clinical Trials As Topic Hospitalization Humans Iontophoresis Perioperative Period Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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