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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | da Silva de Assis, Helena Cristina Sánchez-Chardi, Alejandro Dos Reis, Renata Cristiane Nicaretta, Lilian Mencinauski, Cinthia Jakobi, Sibelle Christine Glaser da Silva, Paulo Henrique Zampronio, Aleksander Roberto Pelletier, Emillien de Oliveira Ribeiro, Ciro Alberto |
| Description | Country affiliation: Brazil Author Affiliation: da Silva de Assis HC ( Departamento de Farmacologia, Universidade Federal do Paraná, Caixa Postal 19031, CEP 81, 531-990 Curitiba, Brazil.) |
| Abstract | This study evaluated the toxic effects of two doses of inorganic lead (PbII) and tributyltin (TBT), separately and together in different exposure times (30 and 60 days) in rats. After exposure, liver, kidney, brain and blood were sampled for histopathological, hematological and enzymatic analysis. The number of peritoneal cells and lipopolysaccharide (LPS)-induced neutrophil migration after exposure was also analyzed. The liver presented necrotic areas in all exposed individuals while hematological and enzymatic parameters showed no changes. TBT, but not PbII, reduced the number of resident peritoneal macrophages. The combination of both toxicants abolished TBT effects at lower doses and even increased the number of macrophages at higher doses. The neutrophil migration was increased by lead and lead associated with TBT. These results confirm the potential hepatotoxicity of these compounds and they may have antagonistic effects on the immune cells when administered alone. The combination of toxicants induced an increased inflammatory response suggesting that lead effects may prevail over TBT reduction on macrophage number. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 1 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 19 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2005-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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