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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Du, Min Wang, Dayong |
| Description | Country affiliation: China Author Affiliation: Du M ( Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Nanjing 210009, China) |
| Abstract | The number of cell body or synapse made by Caenorhabditis elegans GABAergic neurons is constant during development. The neurotoxic effects of metal (Pb, Hg, Cu, Cd, Cr, and Mn) exposure on GABAergic motor neurons were investigated in C. elegans. Exposure to examined metals could not alter the position of GABA neurons, whereas exposure to high concentrations (75µM and 200µM) of metals caused noticeable axonal degeneration and neuronal loss in nerve cords, suggesting neurodegeneration will be induced by metal exposure to different degrees. In addition, exposure to Pb, Hg, Cu, and Cd at the low concentration (2.5µM) could also induce obviously neuronal loss. Moreover, exposure to high concentrations (75µM and/or 200µM) of most of examined metals significantly reduced the relative size and fluorescent intensities of AVL, RMEs, and RIS neurons. Therefore, the neurodegeneration and abnormal structures may be formed in GABAergic motor neurons after metal exposure, and the endpoint of neuronal loss will be useful for the neurotoxicity assessment from trace metal exposure. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Journal | Environmental Toxicology and Pharmacology |
| Volume Number | 27 |
| e-ISSN | 18727077 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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