NDLI: High-dose dibutyl phthalate improves performance of F1 generation male rats in spatial learning and increases hippocampal BDNF expression independent on p-CREB immunocontent.

Please wait, while we are loading the content...

High-dose dibutyl phthalate improves performance of F1 generation male rats in spatial learning and increases hippocampal BDNF expression independent on p-CREB immunocontent.

Diclofenac-enriched artificial sediment induces oxidative stress in Hyalella azteca.

Influence of cypermethrin toxicity on ionic regulation and gill Na(+)/K(+)-ATPase activity of a freshwater teleost fish Cyprinus carpio.

Inhibitory effect of morin on DMH-induced biochemical changes and aberrant crypt foci formation in experimental colon carcinogenesis.

Bioenergetics and DNA alteration of normal human fibroblasts by hexavalent chromium.

Protective effect of Corchorus olitorius leaves against arsenic-induced oxidative stress in rat brain.

Role of vitamin E in preventing acute mercury toxicity in rat.

Response of human DNA polymerase Î¹ promoter to N-methyl-N'-nitro-N-nitrosoguanidine.

Effects of maternal cadmium administration on development of monoaminergic, GABAergic and glutamatergic systems.

Histopathological and proteomic analysis of hepatic tissue from adult male zebrafish exposed to 17ß-estradiol.

Year: 2009 Volume: 28

Year: 2009 Volume: 27

Year: 2008 Volume: 26

Year: 2008 Volume: 25

Year: 2007 Volume: 24

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Year: 2006 Volume: 21

Year: 2005 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2004 Volume: 17

Year: 2004 Volume: 16

Year: 2004 Volume: 15

Year: 2003 Volume: 15

Year: 2003 Volume: 14

Year: 2003 Volume: 13

Year: 1996 Volume: 2

Year: 1996 Volume: 1

High-dose dibutyl phthalate improves performance of F1 generation male rats in spatial learning and increases hippocampal BDNF expression independent on p-CREB immunocontent.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yuanfeng Li, Tao Zhuang, Meizhu Wang, Kailiang Zhang, Juan Shi, Nian
Description	Country affiliation: China Author Affiliation: Li Y ( Department of Health Toxicology, MOE Key Laboratory of Environmental and Health, Tongji Medical College of Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan 430030, Hubei, China.)
Abstract	Dibutyl phthalate (DBP), an important representative of endocrine disrupting chemical, is suspected of affecting the cognitive function of humans and animals. In this study, effects of DBP on maze performance in male rats were evaluated by spatial learning tasks; the effects of DBP on the expression of brain-derived neurotrophic factor (BDNF) were also analyzed in both mRNA and mature protein levels in the hippocampus, with intent to investigate the possible mechanism underlying the behavioral findings. Pregnant Wistar rats were treated orally by gavage with 0, 25, 75, 225 and 675mgDBP/kgBW/day from gestational day (GD) 6 to postnatal day (PND) 21, and then the weaned offspring continued receiving the same treatment till PND 28. We found that male pups treated with high-dose DBP showed enhancement in spatial acquisition in a Morris water maze during PNDs 30-33, and displayed better retention of spatial memory in a probe trial after a reverse trail during PNDs 60-62. Real-time PCR and western blotting analysis of the hippocampus from DBP-treated male rats on PND 21 revealed an increase in BDNF expression, compared to the vehicle-matched control. BDNF variant III, a transcription promoted by active CREB (i.e. p-CREB), as well as the immunocontent of p-CREB, was scarcely altered by the treatment. Our results suggest that developmental treatment with high-dose DBP improves spatial memory in male rats, and this effect may be related to an increase in BDNF expression in the hippocampus in a p-CREB independent route.
File Format	HTM / HTML
ISSN	13826689
Issue Number	1
Journal	Environmental Toxicology and Pharmacology
Volume Number	29
e-ISSN	18727077
Language	English
Publisher	Elsevier
Publisher Date	2010-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of dibutyl phthalate on expression of connexin 43 and testosterone production of leydig cells in adult rats.

Time-Response Effects of Testicular Gene Expression Profiles in Sprague-Dawley Male Rats Treated with Di(n-Butyl) Phthalate

P.721 Hippocampal apoptosis, neurogenesis suppression, BDNF, TrkB, CREB expression in depressed female and male rats

Chronic toxicity of diethyl phthalate-A three generation lactational and gestational exposure study on male Wistar rats.

Effects of maternal stress during pregnancy on learning and memory via hippocampal BDNF, Arc (Arg3.1) expression in offspring.

Identification of genes induced by dibutyl phthalate in human thyroid follicular FTC-238 cells

Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats

Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats.

Effects of maternal exposure to di-n-butyl phthalate during pregnancy and breastfeeding on ovarian development and function of F1 female rats.

High-dose dibutyl phthalate improves performance of F1 generation male rats in spatial learning and increases hippocampal BDNF expression independent on p-CREB immunocontent.

Similar Documents

Effect of dibutyl phthalate on expression of connexin 43 and testosterone production of leydig cells in adult rats.

Time-Response Effects of Testicular Gene Expression Profiles in Sprague-Dawley Male Rats Treated with Di(n-Butyl) Phthalate

P.721 Hippocampal apoptosis, neurogenesis suppression, BDNF, TrkB, CREB expression in depressed female and male rats

Chronic toxicity of diethyl phthalate-A three generation lactational and gestational exposure study on male Wistar rats.

Effects of maternal stress during pregnancy on learning and memory via hippocampal BDNF, Arc (Arg3.1) expression in offspring.

Identification of genes induced by dibutyl phthalate in human thyroid follicular FTC-238 cells

Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats

Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats.

Effects of maternal exposure to di-n-butyl phthalate during pregnancy and breastfeeding on ovarian development and function of F1 female rats.

High-dose dibutyl phthalate improves performance of F1 generation male rats in spatial learning and increases hippocampal BDNF expression independent on p-CREB immunocontent.