NDLI: Methylation capacity of arsenic and skin lesions in smelter plant workers.

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Methylation capacity of arsenic and skin lesions in smelter plant workers.

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Methylation capacity of arsenic and skin lesions in smelter plant workers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wen, Jinghua Wen, Weihua Li, Liang Liu, Hua
Spatial Coverage	China
Description	Author Affiliation: Wen J ( Guizhou University of Finance and Economics, No. 276, Chongguan Road, Guiyang, Guizhou 550004, People's Republic of China.)
Abstract	Potential occupational arsenic exposure is a significant problem in smelting plants. The metabolites containing arsenic with an oxidation of +3 have been considered more cytotoxic and genotoxic than their parent inorganic species. The current study examined the capacity of arsenic methylation and its risk on skin lesions. The primary aim of this study is to determine if methylation capacity, as measured by urinary arsenic metabolites, differed in workers with skin lesions compared to workers without skin lesions. Hydride generation-atomic absorption spectrometry was used to determine three arsenic species in urine of workers who had been working in arsenic plants, and primary and secondary methylation indexes were calculated. Skin lesions were examined at the same time. Many workers had obvious skin lesions (36/91). The mean concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in urine of workers are obviously higher than those of the control group. There are more iAs, MMA, and DMA in urine, higher MMA%, lower iAs% for workers with skin lesions compared with those without skin lesions. Workers with skin lesions have the lowest SMI (3.50±1.21), and they may be in danger. Our results support the viewpoint that individuals who metabolize inorganic arsenic to MMA easily, but metabolize MMA to DMA difficulty have more risk of skin lesions.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	34
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2012-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Arsenic Pharmacokinetics Arsenicals Urine Cacodylic Acid Occupational Diseases Skin Diseases Adult Toxicity Case-control Studies China Epidemiology Environmental Monitoring Female Humans Male Metallurgy Methylation Middle Aged Occupational Exposure Adverse Effects Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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